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人工流产导致严重并发症的风险:个人特征会产生影响吗?

The risk of serious complications from induced abortion: do personal characteristics make a difference?

作者信息

Buehler J W, Schulz K F, Grimes D A, Hogue C J

出版信息

Am J Obstet Gynecol. 1985 Sep 1;153(1):14-20. doi: 10.1016/0002-9378(85)90582-4.

DOI:10.1016/0002-9378(85)90582-4
PMID:4036997
Abstract

We examined the age, gestational age, parity, race, and number of previous spontaneous and induced abortions of 82,030 women who obtained abortions at less than or equal to 24 weeks' gestation. Among these women, 342 (0.4%) had serious complications, including 130 (0.2%) with fever greater than or equal to 38 degrees C for 3 or more days, 172 (0.2%) who required transfusions, 67 (0.1%) who required unintended surgery, and three who died. Factors significantly (p less than 0.05) associated with serious complications varied by period of gestation, including previous induced abortions (adjusted relative risk = 1.57, 95% confidence interval = 1.03 to 2.40) for procedures done at less than or equal to 12 weeks' gestation, advancing age (relative risk for a 5-year increment = 1.12, 95% confidence interval = 1.01 to 1.24), and advancing gestational age (relative risk for a 2-week increment = 1.50, 95% confidence interval = 1.43 to 1.57) for procedures done at greater than 12 weeks, and greater than or equal to 1 previous delivery (relative risk = 1.34, 95% confidence interval = 1.03 to 1.75) for all gestational ages. Although Hispanic women had higher rates of complications compared with white women, data were not available to control for socioeconomic status in comparing race groups. There was no significant association between previous spontaneous abortions and serious complications. Risk patterns were similar, but not identical, when fever, operation, and transfusion were considered separately.

摘要

我们调查了82030名在妊娠24周及以内进行流产的女性的年龄、孕周、产次、种族以及既往自然流产和人工流产的次数。在这些女性中,342人(0.4%)出现了严重并发症,其中130人(0.2%)发热≥38摄氏度持续3天或更长时间,172人(0.2%)需要输血,67人(0.1%)需要进行非计划手术,还有3人死亡。与严重并发症显著相关(p<0.05)的因素因孕周不同而有所差异,包括妊娠12周及以内进行的手术中既往人工流产史(校正相对风险=1.57,95%置信区间=1.03至2.40)、年龄增长(每增加5岁的相对风险=1.12,95%置信区间=1.01至1.24)以及妊娠12周以上进行的手术中孕周增加(每增加2周的相对风险=1.50,95%置信区间=1.43至1.57),所有孕周中既往有≥1次分娩史(相对风险=1.34,95%置信区间=1.03至1.75)。尽管西班牙裔女性的并发症发生率高于白人女性,但在比较种族群体时没有可用于控制社会经济地位的数据。既往自然流产与严重并发症之间无显著关联。分别考虑发热、手术和输血时,风险模式相似但不完全相同。

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