Gunja-Smith Z, Woessner J F
Am J Obstet Gynecol. 1985 Sep 1;153(1):92-5. doi: 10.1016/0002-9378(85)90602-7.
During pregnancy the collagen content of the human uterus increases sevenfold and the elastin content increases fourfold to fivefold. The stable pyridinoline cross-link is found in uterine collagen at a level of 0.11 mol per mole of collagen. The same ratio, or a higher one, is found at the end of pregnancy, indicating that pyridinoline synthesis keeps pace with the rapid synthesis of collagen. This cross-link would participate in the maintenance of high mechanical strength of the uterus needed during parturition. Uterine elastin contains 2.4 residues of desmosine plus isodesmosine in 1000 residues of amino acids. This value falls to 0.95 at term, indicating that synthesis of desmosines does not keep pace with the synthesis of elastin. Therefore, desmosine measurements do not provide an accurate index of elastin changes in pregnancy. Collagen and elastin contents in nongravid uteri increase with successive pregnancies; the cross-links remain constant during this change.
在怀孕期间，人类子宫的胶原蛋白含量增加了七倍，弹性蛋白含量增加了四倍至五倍。在子宫胶原蛋白中发现稳定的吡啶啉交联，其水平为每摩尔胶原蛋白0.11摩尔。在妊娠末期发现相同的比例或更高的比例，表明吡啶啉的合成与胶原蛋白的快速合成同步。这种交联将参与维持分娩期间所需的子宫高机械强度。子宫弹性蛋白在1000个氨基酸残基中含有2.4个锁链素加异锁链素残基。足月时该值降至0.95，表明锁链素的合成与弹性蛋白的合成不同步。因此，锁链素测量不能提供怀孕期间弹性蛋白变化的准确指标。非妊娠子宫中的胶原蛋白和弹性蛋白含量随着连续怀孕而增加；在此变化过程中交联保持不变。
