Li Huan, Guo Qi, Feng Yi, Liao Lingjie, Li Qi, Xing Hui, Wang Zheng
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Jilin Provincial Center for Disease Control and Prevention, Changchun, China.
AIDS Res Hum Retroviruses. 2025 Jul;41(7):366-371. doi: 10.1089/aid.2024.0131. Epub 2025 May 15.
Although HIV-1 infection has now become a treatable chronic condition and not the deadly illness it once was, the costs of that treatment are substantial, and each infection prevented saves both financial and other costs. In China, the most predominant subtypes are CRF07_BC, CRF01_AE, and CRF55_01B, and the various second-generation recombinants are produced from the recombination between these subtypes. HIV full-length genome sequences can provide important information on their epidemiology. In this study, we identified two unique recombinant forms (URFs) designated as JLCC230106 and XJWQ230011, which are composed of CRF01_AE/CRF07_BC and CRF07_BC/CRF55_01B, respectively. Phylogenetic and recombinant analyses utilizing near-full-length genome (NFLG) confirmed that these URFs originated from CRF01_AE/CRF07_BC and CRF07_BC/CRF55_01B strains. The emergence of novel recombinants is increasing the genetic diversity of HIV in China. This information can be shared with clinicians, human behavior specialists, or public health policymakers and used as an aid in discovering which methods are best or most cost-effective in combating the spread of HIV.
尽管HIV-1感染如今已成为一种可治疗的慢性病，而非曾经的致命疾病，但治疗成本高昂，每预防一例感染都能节省财政成本和其他成本。在中国，最主要的亚型是CRF07_BC、CRF01_AE和CRF55_01B，各种第二代重组体由这些亚型之间的重组产生。HIV全长基因组序列可为其流行病学提供重要信息。在本研究中，我们鉴定出两种独特的重组形式（URF），分别命名为JLCC230106和XJWQ230011，它们分别由CRF01_AE/CRF07_BC和CRF07_BC/CRF55_01B组成。利用近全长基因组（NFLG）进行的系统发育和重组分析证实，这些URF源自CRF01_AE/CRF07_BC和CRF07_BC/CRF55_01B毒株。新型重组体的出现正在增加中国HIV的遗传多样性。这些信息可与临床医生、人类行为专家或公共卫生政策制定者分享，并用于帮助发现哪些方法在抗击HIV传播方面最佳或最具成本效益。
