Luo Jun, Singh Jujhar, Deng Yongming
Department of Chemistry and Chemical Biology, Indiana University Indianapolis, Indianapolis, Indiana 46202, United States.
Tetrahedron. 2025 Aug 1;181. doi: 10.1016/j.tet.2025.134683. Epub 2025 Apr 26.
Pyridine -oxides have been well established as a class of potent hydrogen-atom-transfer (HAT) catalysts for C-H functionalization of unactivated alkanes and activated C-H substrates. The combination of acridine derivatives and Lewis acids forms photocatalysts that are able to photo-oxidize pyridine -oxides to generate -oxide radicals upon irradiation with visible light. Herein, we described a photocatalytic C-H functionalization utilizing acridine-Lewis acid complexes and pyridine -oxide based HAT catalysts. The readily available and facilely tunable photocatalytic system of acridine-Lewis acid complexes and pyridine -oxides enables a broad range of substrates with high reactivities (up to 97% yield).
吡啶-N-氧化物已被充分确立为一类用于未活化烷烃和活化C-H底物的C-H官能化的高效氢原子转移（HAT）催化剂。吖啶衍生物与路易斯酸的组合形成光催化剂，该光催化剂能够在可见光照射下将吡啶-N-氧化物光氧化以产生-N-氧化物自由基。在此，我们描述了一种利用吖啶-路易斯酸配合物和基于吡啶-N-氧化物的HAT催化剂的光催化C-H官能化反应。吖啶-路易斯酸配合物和吡啶-N-氧化物这种易于获得且易于调节的光催化体系能够使多种底物具有高反应活性（产率高达97%）。
