阿托伐他汀联合糖皮质激素保守治疗硬膜外血肿：病例报告及文献复习
Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review.
作者信息
Wu Chenrui, Tian Yu, Zhao Ruichen, Chen Runfang, Xu Chuanlin, Huang Jinsheng, Jiang Rongcai
机构信息
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Front Surg. 2025 Apr 30;12:1587988. doi: 10.3389/fsurg.2025.1587988. eCollection 2025.
Epidural hematomas (EDH), typically requiring surgery, may be managed conservatively in select patients. We investigated atorvastatin (10 mg/day) combined with dexamethasone (2.25 mg/day) as conservative therapy in six EDH patients (GCS ≥ 13, volume < 30 ml) post-trauma. All patients recovered fully without surgery, and literatures support conservative care for stable EDH. Our findings suggest this combination therapy may promote hematoma absorption. In conclusion, atorvastatin/dexamethasone shows promise as a non-surgical EDH option, warranting further investigation.
硬膜外血肿（EDH）通常需要手术治疗，但在某些特定患者中也可采用保守治疗。我们对6例创伤后硬膜外血肿患者（格拉斯哥昏迷评分≥13分，血肿体积<30 ml）进行了研究，采用阿托伐他汀（10毫克/天）联合地塞米松（2.25毫克/天）作为保守治疗方法。所有患者均未接受手术而完全康复，并且有文献支持对稳定型硬膜外血肿进行保守治疗。我们的研究结果表明，这种联合治疗可能会促进血肿吸收。总之，阿托伐他汀/地塞米松作为硬膜外血肿的非手术治疗选择显示出前景，值得进一步研究。
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