Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
BMC Gastroenterol. 2022 Aug 5;22(1):372. doi: 10.1186/s12876-022-02457-w.
Eccentric exhaustive exercise (EEE) training has been known as a promising training modality to enhance performance and stimulate adaptation in healthy individuals or patients that might also cause abnormal liver enzymes and lipid profiles. Vitamin D (Vit D) supplementation is believed to improve the condition of Non-Alcoholic Fatty Liver Disease (NAFLD) patients. However, there is limited evidence on the effect of Vit D supplementation on the EEE-induced alterations. This study aimed to investigate the effect of short-term supplementation of Vit D on the liver enzymes and lipid profile alterations following EEE in overweight women with NAFLD.
In this clinical trial, 22 overweight women with NAFLD were randomly divided into experimental and control (n = 11 in each). The experimental group consumed 2000 IU of Vit D per day for six weeks; the control group consumed a lactose placebo daily with the same color, shape, and warmth percentage. Two treadmill EEE sessions were performed before and after the six-week Vit D supplementation. Blood was taken from the antecubital vein to measure the liver enzymes, lipid profile, and Vit D at four stages: Pre 1(before the first EEE session), Post 1(after the first EEE session), Pre 2 (before the second EEE session), and Post 2 (after the second EEE session).
The results indicate that Vit D supplementation significantly reduced Bodyweight (BW; P = 0.047), Body Mass Index (BMI; P = 0.044), Body Fat Percentage (BFP; P = 0.001), and Waist Hip Ratio (WHR; P = 0.001) in the experimental group. Additionally, the results showed increased liver enzymes (ALT, AST, and GGT) and lipid profile (TC, TG, and LDL) following EEE. While the HDL levels decreased significantly after EEE. Compared with control, the results of the independent t-test showed significantly lower ALT (P = 0.001; P = 0.001), AST (P = 0.001; P = 0.001), and GGT (P = 0.001; P = 0.001); while significantly higher Vit D (P = 0.001, P = 0.001) in the experimental in both Pre 2 and Post 2; receptively. Also, significantly lower TC (P = 0.001; P = 0.001), TG (P = 0.048; P = 0.001), and LDL (P = 0.001; P = 0.001); while significantly higher HDL (P = 0.001, P = 0.001) were observed in the experimental group compared to the control in both Pre 2 and Post 2; receptively.
Vit D supplementation reduces the liver enzymes and improves lipid profile alterations following EEE in overweight women with NAFLD. Thus, Vit D supplementation can be considered a functional supplement to improve the EEE-induced alteration.
The trial was in the Iranian Clinical Trial Registration Center under the (IRCT20201130049538N1) on 05/07/2021.
离心力耗尽运动（EEE）训练已被证明是一种有前途的训练方式，可以提高健康个体或患者的表现并刺激适应能力，也可能导致异常的肝酶和血脂谱。维生素 D（Vit D）补充剂被认为可以改善非酒精性脂肪肝疾病（NAFLD）患者的病情。然而，关于 Vit D 补充对 EEE 引起的改变的影响的证据有限。本研究旨在探讨短期补充 Vit D 对超重女性 NAFLD 患者 EEE 后肝酶和血脂谱改变的影响。
在这项临床试验中，22 名超重 NAFLD 女性被随机分为实验组和对照组（每组 11 名）。实验组每天服用 2000 IU Vit D，持续六周；对照组每天服用乳糖安慰剂，颜色、形状和温暖度相同。在六周 Vit D 补充前后进行两次跑步机 EEE 训练。在四个阶段从肘静脉采血以测量肝酶、血脂谱和 Vit D：Pre 1（第一次 EEE 训练前）、Post 1（第一次 EEE 训练后）、Pre 2（第二次 EEE 训练前）和 Post 2（第二次 EEE 训练后）。
结果表明，实验组 Vit D 补充显著降低了体重（BW；P = 0.047）、体重指数（BMI；P = 0.044）、体脂肪百分比（BFP；P = 0.001）和腰臀比（WHR；P = 0.001）。此外，结果显示 EEE 后肝酶（ALT、AST 和 GGT）和血脂谱（TC、TG 和 LDL）升高，而高密度脂蛋白（HDL）水平在 EEE 后显著下降。与对照组相比，独立 t 检验的结果显示，实验组的 ALT（P = 0.001；P = 0.001）、AST（P = 0.001；P = 0.001）和 GGT（P = 0.001；P = 0.001）明显较低；而 Vit D（P = 0.001，P = 0.001）明显较高。此外，实验组的 TC（P = 0.001；P = 0.001）、TG（P = 0.048；P = 0.001）和 LDL（P = 0.001；P = 0.001）明显较低，而 HDL（P = 0.001，P = 0.001）明显较高。
Vit D 补充可降低超重女性 NAFLD 患者 EEE 后肝酶和血脂谱的改变。因此，Vit D 补充可以被认为是一种功能性补充剂，以改善 EEE 引起的改变。
该试验在伊朗临床试验注册中心（IRCT20201130049538N1）注册，注册日期为 2021 年 7 月 5 日。
