James Lisa M, Georgopoulos Apostolos P
The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN, 55417, USA.
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
J Immunol Sci. 2021 Aug 19;5(3):22-28. doi: 10.29245/2578-3009/2021/3.1221.
Very few studies have evaluated associations of human leukocyte antigen (HLA) with motor neuron diseases (MND). Using an immunogenetic epidemiological approach, we identified a population-level HLA profile for MND by evaluating the correlations between the population frequencies of 127 HLA Class I and II alleles and the population prevalence of MND in 14 Continental Western European countries. The results demonstrated that significantly more HLA alleles, particularly for Class I, were negatively associated with the population prevalence of MND, suggesting a preponderance of protective vs susceptibility effects. The findings add to the limited literature implicating HLA in MND and considering the role of HLA in immune system responses to pathogens, suggest a potential influence of pathogens in MND.
极少有研究评估人类白细胞抗原（HLA）与运动神经元病（MND）之间的关联。我们采用免疫遗传学流行病学方法，通过评估127个HLA I类和II类等位基因的人群频率与14个西欧大陆国家MND的人群患病率之间的相关性，确定了MND的人群水平HLA谱。结果表明，与MND人群患病率呈负相关的HLA等位基因明显更多，尤其是I类等位基因，这表明保护作用相对于易感性作用占优势。这些发现增加了关于HLA与MND相关的有限文献，并鉴于HLA在免疫系统对病原体反应中的作用，提示病原体在MND中可能具有影响。
