Wu Doudou, Cai Rui, Pang Ying, Ma Jie, Chen Bailin, Bao Siran, Zheng Kaili, Jiang Wenbo, Qi Yiming, Li Nuo
Department of Integrative Traditional Chinese and Western Medicine, Beijing University of Chinese Medicine, Beijing, China.
Department of Chinese Medicine, Beijing Nuclear Industry Hospital, Beijing, China.
Clin Exp Med. 2025 May 15;25(1):161. doi: 10.1007/s10238-025-01693-0.
In recent years, the prevalence of uveitis among patients with psoriasis has shown a noticeable upward trend. Previous studies have investigated the immunological mechanisms underlying the potential connection between psoriasis and uveitis, but systematic studies exploring their bidirectional relationship is absent. This study aims to systematically evaluate the bidirectional association between psoriasis and uveitis to provide evidence.
We thoroughly searched PubMed, Embase, and the Cochrane Library for relevant observational studies published from the inception of these databases up to Mar 11th, 2024. Our systematic review was based on priori protocol pre-registered in PROSPERO (No. CRD42024522464). Risk and bias assessments were analyzed using STATA 16.0.
We analyzed the results from 7 studies involving 81,775,820 subjects. The results showed that the incidence of uveitis was higher in patients with psoriasis compared to patients without psoriasis (OR = 1.16, 95% CI: 1.11-1.21). At the same time, patients with uveitis showed heightened susceptibility to psoriasis (OR = 1.52, 95% CI: 1.34-1.70, I: 90.6%, P < 0.01). The subgroup analysis found that uveitis affects the severity and type of psoriasis.
The current systematic review and meta-analysis found a bidirectional association between psoriasis and uveitis. Notably, patients with severe psoriasis and psoriasis with joint symptoms should be informed about their increased risk to developing uveitis.
近年来，银屑病患者中葡萄膜炎的患病率呈显著上升趋势。以往的研究探讨了银屑病与葡萄膜炎潜在关联背后的免疫机制，但缺乏对它们双向关系的系统性研究。本研究旨在系统评估银屑病与葡萄膜炎之间的双向关联，以提供证据。
我们全面检索了PubMed、Embase和Cochrane图书馆，查找从这些数据库建立至2024年3月11日发表的相关观察性研究。我们的系统评价基于在PROSPERO预先注册的先验方案（编号：CRD42024522464）。使用STATA 16.0进行风险和偏倚评估分析。
我们分析了7项研究的结果，涉及81775820名受试者。结果显示，与无银屑病的患者相比，银屑病患者中葡萄膜炎的发病率更高（OR = 1.16，95%CI：1.11 - 1.21）。同时，葡萄膜炎患者患银屑病的易感性更高（OR = 1.52，95%CI：1.34 - 1.70，I²：90.6%，P < 0.01）。亚组分析发现葡萄膜炎会影响银屑病的严重程度和类型。
当前的系统评价和荟萃分析发现银屑病与葡萄膜炎之间存在双向关联。值得注意的是，应告知重度银屑病患者和伴有关节症状的银屑病患者其患葡萄膜炎风险增加。
