Lam Megan, Steen Jeremy, Lu Justin Di, Vender Ronald
12362 Michael G. DeGroote School of Medicine, Hamilton, ON, Canada.
62703 Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
J Cutan Med Surg. 2020 Nov/Dec;24(6):601-607. doi: 10.1177/1203475420952420. Epub 2020 Aug 31.
The systemic effects and comorbidities of psoriasis include ocular disorders, such as uveitis. Patients with psoriatic arthritis in particular have been demonstrated to have an elevated risk for developing uveitis. Presently, the risk of uveitis in psoriasis has yet to be fully elucidated and this systematic review seeks to address this gap.
To examine the prevalence and incidence of uveitis in psoriasis patients compared to non-psoriasis patients.
We conducted a systematic review search on MEDLINE, Embase, and CENTRAL electronic databases with no lower limit on year of publication.
Fourteen articles met our inclusion criteria, with a total of 234 143 psoriasis subjects. Two studies found that participants with severe psoriasis were at a greater risk of uveitis than those with mild psoriasis. A random-effects meta-analysis of the 3 studies, which reported risk of incidence of uveitis in psoriasis patients compared to non-psoriasis controls, found a pooled risk ratio of 1.29 (95% CI, 1.10-1.51), indicating an increased risk of uveitis in psoriasis. Three studies compared risk of uveitis in psoriatic arthritis with psoriasis-only participants, all finding that psoriatic arthritis was associated with a greater risk of uveitis.
In summary, our findings suggest that psoriasis is associated with an increased risk of uveitis, with or without psoriatic arthritis.
银屑病的全身影响和合并症包括眼部疾病，如葡萄膜炎。尤其已证实银屑病关节炎患者发生葡萄膜炎的风险升高。目前，银屑病中葡萄膜炎的风险尚未完全阐明，本系统评价旨在填补这一空白。
比较银屑病患者与非银屑病患者葡萄膜炎的患病率和发病率。
我们在MEDLINE、Embase和CENTRAL电子数据库上进行了系统评价检索，对发表年份无下限要求。
14篇文章符合我们的纳入标准，共有234143名银屑病受试者。两项研究发现，重度银屑病参与者发生葡萄膜炎的风险高于轻度银屑病参与者。对3项研究进行的随机效应荟萃分析报告了银屑病患者与非银屑病对照相比葡萄膜炎的发病风险，发现合并风险比为1.29（95%CI，1.10-1.51），表明银屑病患者发生葡萄膜炎的风险增加。三项研究比较了银屑病关节炎患者与仅患银屑病参与者的葡萄膜炎风险，均发现银屑病关节炎与葡萄膜炎风险增加有关。
总之，我们的研究结果表明，无论有无银屑病关节炎，银屑病都与葡萄膜炎风险增加有关。
