Choudat D, Neukirch F, Brochard P, Barrat G, Marsac J, Conso F, Philbert M
Service de pathologie professionnelle, Hôpital Cochin, Paris, France.
Br J Ind Med. 1988 Jun;45(6):376-80. doi: 10.1136/oem.45.6.376.
Respiratory manifestations have been reported after exposure to hydroquinone and to methionine. One hundred and three men in the same chemical plant were divided into three groups according to their exposure and compared by questionnaire, respiratory functional tests with methacholine then salbutamol challenges, and measurements of serum immunoglobulins G and E. Group H included 33 workers exposed to hydroquinone, trimethyl-hydroquinone, and retinene-hydroquinone. Group M included 15 workers exposed to methionine. Group C was a control group of 55 workers. The prevalence of respiratory symptoms was higher in the two exposed groups. Before challenges, pulmonary function values were significantly lower in groups H and M than those in group C. The challenges induced significant variations in the three groups but these variations were less pronounced in group M than in the other groups. The level of immunoglobulin G in group H (m +/- SD = 12.5 gram/liter +/- 2.6) was significantly higher than in group C (10.6 gram/liter +/- 2.4; p less than 0.002). The level of immunoglobulin E in group H (m = 140 IU/l) was also higher in group C (109 IU/l) but this difference was not significant. These findings suggest that exposure to methionine and to hydroquinone and its derivatives induce ventilatory impairment, perhaps by an immunological mechanism.
接触对苯二酚和蛋氨酸后曾有呼吸道表现的报道。同一家化工厂的103名男性根据接触情况分为三组，并通过问卷调查、用乙酰甲胆碱然后沙丁胺醇激发的呼吸功能测试以及血清免疫球蛋白G和E的测量进行比较。H组包括33名接触对苯二酚、三甲基对苯二酚和视黄醛对苯二酚的工人。M组包括15名接触蛋氨酸的工人。C组是由55名工人组成的对照组。两个接触组的呼吸道症状患病率较高。激发前，H组和M组的肺功能值显著低于C组。激发在三组中引起了显著变化，但M组的这些变化不如其他组明显。H组免疫球蛋白G水平（m±SD = 12.5克/升±2.6）显著高于C组（10.6克/升±2.4；p＜0.002）。H组免疫球蛋白E水平（m = 140 IU/l）也高于C组（109 IU/l），但这种差异不显著。这些发现表明，接触蛋氨酸、对苯二酚及其衍生物可能通过免疫机制导致通气功能损害。
