Normandale J P, Schmulian C, Paterson J L, Burrin J, Morgan M, Hall G M
Anaesthesia. 1985 Aug;40(8):748-53. doi: 10.1111/j.1365-2044.1985.tb10998.x.
The effect of the administration of diamorphine 10 mg epidurally on the metabolic response to cholecystectomy was investigated and compared with a control group of patients given intravenous papaveretum. There were no significant differences in blood glucose, lactate and pyruvate, and plasma nonesterified fatty acid values between the epidural diamorphine group and the control group. Plasma cortisol concentrations were significantly lower in the epidural diamorphine group postoperatively and this was associated with a marked improvement in pain relief. We conclude that epidural opiates do not directly influence the metabolic response to surgery, but decrease the cortisol response postoperatively secondary to improved analgesia.
研究了硬膜外注射10毫克二醋吗啡对胆囊切除术代谢反应的影响，并与静脉注射阿片全碱的对照组患者进行了比较。硬膜外二醋吗啡组与对照组之间的血糖、乳酸、丙酮酸和血浆非酯化脂肪酸值无显著差异。硬膜外二醋吗啡组术后血浆皮质醇浓度显著降低，这与疼痛缓解的显著改善有关。我们得出结论，硬膜外使用阿片类药物不会直接影响手术的代谢反应，但会因镇痛改善而降低术后皮质醇反应。
