Cooper G M, Holdcroft A, Hall G M, Alaghband-Zadeh J
Can Anaesth Soc J. 1979 Sep;26(5):381-5. doi: 10.1007/BF03006452.
The effect of epidural blockade on the metabolic and hormonal responses to pelvic surgery was investigated in 14 female patients. Central venous blood samples were collected every 30 minutes and analysed for free fatty acids, glycerol, beta-hydroxybutyrate, acetoacetate, glucose, lactate, pyruvate, cortisol and growth hormone concentrations. There was no change in fat and glucose metabolism except for a transient decrease in lipolysis after 30 minutes of surgery. Cortisol and growth hormone values were significantly increased (p less than 0.01) after 60 minutes. A small but statistically significant increase in blood lactate concentration was observed (p less than 0.01) and the concept of a "metabolic V/Q" abnormality is postulated to explain the lacticacidaemia.
对14名女性患者研究了硬膜外阻滞对盆腔手术代谢和激素反应的影响。每30分钟采集一次中心静脉血样本，分析游离脂肪酸、甘油、β-羟基丁酸、乙酰乙酸、葡萄糖、乳酸、丙酮酸、皮质醇和生长激素浓度。除手术30分钟后脂解有短暂下降外，脂肪和葡萄糖代谢无变化。60分钟后皮质醇和生长激素值显著升高（p<0.01）。观察到血乳酸浓度有小幅度但具有统计学意义的升高（p<0.01），并假设存在“代谢性V/Q”异常来解释乳酸性酸中毒。
