Yin Shuijing, Qiu Yu
Department of Urology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
PLoS One. 2025 May 15;20(5):e0323677. doi: 10.1371/journal.pone.0323677. eCollection 2025.
Oxidative stress contributes to benign prostatic hyperplasia (BPH) pathogenesis, but its role in BPH with bladder diverticulum is unclear.
This prospective cohort study compared 126 BPH patients at the Second Hospital of Harbin Medical University. The study involved two groups (n = 63 for each group): group A, comprising patients with BPH, and group B, consisting of BPH patients with bladder diverticulum. Ultrasound imaging and CT scans were employed to assess the features of BPH and bladder diverticulum, respectively. Various clinical parameters and oxidative stress biomarkers were compared between the groups.
Group B exhibited significantly higher creatinine (101.8 ± 27.6 µmol/L vs. 56.1 ± 23.6 µmol/L, p < 0.0001), WBC counts (7.0 ± 1.9 vs. 4.2 ± 1.3 × 10⁹/L, p < 0.0001), residual urine volume (400.1 ± 252.0 mL vs. 150.7 ± 93.9 mL, p < 0.0001), and oxidative stress markers, including 8-OHdG (1.93 ± 0.58 vs. 1.70 ± 0.73 ng/mg creatinine, p = 0.014) and MDA (2.46 ± 0.57 vs. 2.03 ± 0.57 μmol/L, p < 0.0001). In group A, 8-OHdG positively correlated with residual urine volume (rho = 0.68) and nitric oxide with bladder wall thickness (rho = 0.70), while quality of life (QoL) negatively correlated with nitric oxide (rho = -0.76). In group B, oxidative stress markers correlated positively with BMI (e.g., homocysteine, rho = 0.69) and bladder wall thickness (e.g., nitric oxide, rho = 0.69), with QoL negatively correlated with uric acid (rho = -0.78).
Bladder diverticulum in BPH patients is associated with elevated oxidative stress, increased inflammation, and impaired bladder function.
氧化应激参与良性前列腺增生（BPH）的发病机制，但其在伴有膀胱憩室的BPH中的作用尚不清楚。
这项前瞻性队列研究比较了哈尔滨医科大学附属第二医院的126例BPH患者。该研究分为两组（每组n = 63）：A组为BPH患者，B组为伴有膀胱憩室的BPH患者。分别采用超声成像和CT扫描评估BPH和膀胱憩室的特征。比较两组之间的各种临床参数和氧化应激生物标志物。
B组的肌酐水平（101.8±27.6 μmol/L对56.1±23.6 μmol/L，p < 0.0001）、白细胞计数（7.0±1.9对4.2±1.3×10⁹/L，p < 0.0001）、残余尿量（400.1±252.0 mL对150.7±93.9 mL，p < 0.0001）以及氧化应激标志物，包括8-羟基脱氧鸟苷（1.93±0.58对1.70±0.73 ng/mg肌酐，p = 0.014）和丙二醛（2.46±0.57对2.03±0.57 μmol/L，p < 0.0001）均显著更高。在A组中，8-羟基脱氧鸟苷与残余尿量呈正相关（rho = 0.68），一氧化氮与膀胱壁厚度呈正相关（rho = 0.70），而生活质量（QoL）与一氧化氮呈负相关（rho = -0.76）。在B组中，氧化应激标志物与体重指数呈正相关（如高半胱氨酸，rho = 0.69），与膀胱壁厚度呈正相关（如一氧化氮，rho = 0.69），QoL与尿酸呈负相关（rho = -0.78）。
BPH患者的膀胱憩室与氧化应激升高、炎症增加和膀胱功能受损有关。
