Fitzmaurice Matilda, Adami Chiara, Ladlow Jane, Tomlinson Francesca, Gittel Claudia
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom; The Ralph Veterinary Referral Centre, Marlow, United Kingdom.
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Vet J. 2025 Aug;312:106372. doi: 10.1016/j.tvjl.2025.106372. Epub 2025 May 13.
The impact of brachycephalic obstructive airway syndrome in dogs (BOAS) on respiratory mechanics is unclear and may affect the choice of ventilation strategies during anaesthesia. This prospective study included 56 client-owned brachycephalic dogs, allocated to be BOAS (n = 26) or non-BOAS dogs (n = 30) based on functional grading. All dogs were anaesthetised using a standardised anaesthetic protocol. Pressure-controlled ventilation was initiated around 30 min post-induction, maintaining peak inspiratory pressure at 7-12 cm HO. Static respiratory compliance (Cstat) was recorded at predetermined time points in sternal, right and left lateral recumbency. Thorax dimensions were assessed with a tape measure. Body surface area (BSA) was calculated and the ratio Cstat/BSA used as the main outcome variable. Comparison of means/medians, analysis of proportions, the Spearman correlation coefficient and both logistic and linear regression were used for data analysis. P < 0.05 was considered statistically significant. Non-BOAS dogs showed significantly higher Cstat/BSA compared to BOAS dogs in sternal (41.6 (31.1-51.8) vs. 32.9 (24.4 - 39.2), respectively, P = 0.028), right lateral (36.2 (25.7 - 46.4) vs. 27.0 (22.7 - 35.6); P = 0.026) and left lateral (33.6 (22.6 - 45.5) vs. 24.6 (18.4 - 32.2); P = 0.020) recumbencies. For all dogs, the Cstat/BSA ratio was higher in sternal compared to lateral recumbencies. BOAS dogs had a significantly shorter distance between thoracic inlet and last rib compared to non-BOAS dogs (20 ± 4 vs. 23 ± 6 cm, respectively; P = 0.043). Reduced respiratory compliance in BOAS-affected dogs should be considered during mechanical ventilation.
短头阻塞性气道综合征（BOAS）对犬类呼吸力学的影响尚不清楚，可能会影响麻醉期间通气策略的选择。这项前瞻性研究纳入了56只客户拥有的短头犬，根据功能分级分为BOAS犬（n = 26）或非BOAS犬（n = 30）。所有犬只均采用标准化麻醉方案进行麻醉。诱导后约30分钟开始压力控制通气，将吸气峰压维持在7 - 12 cm H₂O。在胸骨位、右侧卧位和左侧卧位的预定时间点记录静态呼吸顺应性（Cstat）。用卷尺评估胸廓尺寸。计算体表面积（BSA），并将Cstat/BSA比值用作主要结局变量。采用均值/中位数比较、比例分析、Spearman相关系数以及逻辑回归和线性回归进行数据分析。P < 0.05被认为具有统计学意义。与BOAS犬相比，非BOAS犬在胸骨位（分别为41.6（31.1 - 51.8）与32.9（24.4 - 39.2），P = 0.028）、右侧卧位（36.2（25.7 - 46.4）与27.0（22.7 - 35.6）；P = 0.026）和左侧卧位（33.6（22.6 - 45.5）与24.6（18.4 - 32.2）；P = 0.020）时的Cstat/BSA显著更高。对于所有犬只，胸骨位的Cstat/BSA比值高于侧卧位。与非BOAS犬相比，BOAS犬胸廓入口与最后一根肋骨之间的距离显著更短（分别为20 ± 4 cm与23 ± 6 cm；P = 0.043）。在机械通气期间应考虑BOAS患犬呼吸顺应性降低的情况。
