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A review on generative AI models for synthetic medical text, time series, and longitudinal data.

作者信息

Loni Mohammad, Poursalim Fatemeh, Asadi Mehdi, Gharehbaghi Arash

机构信息

School of Innovation, Design and Engineering, Mälardalen University, Västerås, Sweden.

Servicehälsan Familjeläkare i Västerås AB, Västerås, Sweden.

出版信息

NPJ Digit Med. 2025 May 15;8(1):281. doi: 10.1038/s41746-024-01409-w.


DOI:10.1038/s41746-024-01409-w
PMID:40374917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12081667/
Abstract

This paper presents the results of a novel scoping review on the practical models for generating three different types of synthetic health records (SHRs): medical text, time series, and longitudinal data. The innovative aspects of the review, which incorporate study objectives, data modality, and research methodology of the reviewed studies, uncover the importance and the scope of the topic for the digital medicine context. In total, 52 publications met the eligibility criteria for generating medical time series (22), longitudinal data (17), and medical text (13). Privacy preservation was found to be the main research objective of the studied papers, along with class imbalance, data scarcity, and data imputation as the other objectives. The adversarial network-based, probabilistic, and large language models exhibited superiority for generating synthetic longitudinal data, time series, and medical texts, respectively. Finding a reliable performance measure to quantify SHR re-identification risk is the major research gap of the topic.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e68/12081667/b0dd54c047eb/41746_2024_1409_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e68/12081667/d808b507f828/41746_2024_1409_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e68/12081667/4c4a3564d8f5/41746_2024_1409_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e68/12081667/b0dd54c047eb/41746_2024_1409_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e68/12081667/d808b507f828/41746_2024_1409_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e68/12081667/4c4a3564d8f5/41746_2024_1409_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e68/12081667/b0dd54c047eb/41746_2024_1409_Fig3_HTML.jpg

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本文引用的文献

[1]
PromptEHR: Conditional Electronic Healthcare Records Generation with Prompt Learning.

Proc Conf Empir Methods Nat Lang Process. 2022-12

[2]
Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy.

NPJ Digit Med. 2024-5-4

[3]
Foundation metrics for evaluating effectiveness of healthcare conversations powered by generative AI.

NPJ Digit Med. 2024-3-29

[4]
Large language models to identify social determinants of health in electronic health records.

NPJ Digit Med. 2024-1-11

[5]
SleepSIM: Conditional GAN-based non-REM sleep EEG Signal Generator.

Annu Int Conf IEEE Eng Med Biol Soc. 2023-7

[6]
A study of generative large language model for medical research and healthcare.

NPJ Digit Med. 2023-11-16

[7]
Synthesize high-dimensional longitudinal electronic health records via hierarchical autoregressive language model.

Nat Commun. 2023-8-31

[8]
Accurate detection of paroxysmal atrial fibrillation with certified-GAN and neural architecture search.

Sci Rep. 2023-7-14

[9]
Diffusion-based conditional ECG generation with structured state space models.

Comput Biol Med. 2023-9

[10]
Improving an Electronic Health Record-Based Clinical Prediction Model Under Label Deficiency: Network-Based Generative Adversarial Semisupervised Approach.

JMIR Med Inform. 2023-6-13

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