Avol E L, Linn W S, Shamoo D A, Valencia L M, Anzar U T, Venet T G, Hackney J D
Am Rev Respir Dis. 1985 Sep;132(3):619-22. doi: 10.1164/arrd.1985.132.3.619.
Healthy volunteers 12 to 15 yr of age (46 boys, 13 girls) were exposed to purified air and to smoggy Los Angeles ambient air on different occasions. The studies were performed in random order approximately 2 wk apart. They included 1 h of continuous bicycle exercise (mean ventilation, 32 L/min) plus brief warm-up and cool-down periods. Symptoms and forced expiratory performance were recorded preexposure in purified air, immediately postexposure, and after 1 h recovery in purified air. Mean exposure temperature was 32 degrees C, and mean relative humidity was 45%. In ambient exposure, pollutant concentrations averaged 0.144 ppm for ozone and 153 micrograms/m3 for total suspended particulates. Group mean FEV1 decreased during ambient exposure (p less than 0.01) and only partially recovered during the following 1 h. Unlike adults studied previously, this subject group reported no significant increase in respiratory symptoms accompanying changes in FEV1. Adolescents may be less aware of early respiratory irritation by oxidants and thus more at risk from ambient exposures than are adults.
12至15岁的健康志愿者（46名男孩，13名女孩）在不同时间分别暴露于净化空气和烟雾弥漫的洛杉矶环境空气中。这些研究以随机顺序进行，间隔约2周。研究包括1小时的持续自行车运动（平均通气量为32升/分钟）以及短暂的热身和冷却期。在净化空气中暴露前、暴露后立即以及在净化空气中恢复1小时后记录症状和用力呼气表现。平均暴露温度为32摄氏度，平均相对湿度为45%。在环境暴露中，臭氧浓度平均为0.144 ppm，总悬浮颗粒物浓度平均为153微克/立方米。在环境暴露期间，组平均第一秒用力呼气量（FEV1）下降（p<0.01），且在随后的1小时内仅部分恢复。与之前研究的成年人不同，该受试者组报告称，伴随FEV1变化的呼吸道症状没有显著增加。青少年可能对氧化剂引起的早期呼吸道刺激不太敏感，因此与成年人相比，他们受环境暴露影响的风险更大。
