Marcus D F, Turgeon P, Aaberg T M, Wiznia R A, Wetzig P C, Bovino J A
Ann Ophthalmol. 1985 Jul;17(7):397-402.
Three cases of papilledema secondary to chronic excessive vitamin A intake are presented, and the optic disk changes are documented with intravenous fluorescein angiography. Two of the three patients reported in this study were symptomatic with blurred vision and systemic complaints. The symptoms of blurred vision and systemic complaints disappeared within one week, and papilledema resolved over several months after discontinuance of vitamin A. The fluorescein angiographic changes observed in the optic disk of patients with hypervitaminosis A are similar to those associated with other known causes of papilledema. Since vitamin A is a nonprescription drug, and its indiscriminate use is potentially great, any history of vitamin ingestion should be elicited during the evaluation of papilledema.
本文报告了3例因长期过量摄入维生素A继发视乳头水肿的病例，并通过静脉注射荧光素血管造影记录了视盘变化。本研究报告的3例患者中有2例出现视力模糊和全身不适症状。视力模糊和全身不适症状在1周内消失，停用维生素A后视乳头水肿在数月内消退。维生素A过多症患者视盘上观察到的荧光素血管造影变化与其他已知视乳头水肿病因相关的变化相似。由于维生素A是非处方药，且其滥用的可能性很大，因此在对视乳头水肿进行评估时应了解任何维生素摄入史。
