Borska Eva, Kviesis Jorens, Ramata-Stunda Anna, Nikolajeva Vizma, Ansone-Bertina Linda, Boroduskis Martins, Klavins Maris
Department of Environmental Science, University of Latvia, Riga, Latvia.
Institute of Microbiology and Biotechnology, University of Latvia, Riga, Latvia.
Front Pharmacol. 2025 May 1;16:1582694. doi: 10.3389/fphar.2025.1582694. eCollection 2025.
Sosnowsky's hogweed ( Manden) is one of the most dangerous invasive plant, notorious with presence of toxic substances. At the same time phytochemistry from perspective of applications in pharmacology, especially lipids have not been much studied. This study aims to analyse lipids of , especially fatty acids, their composition, metabolism patterns and biological activity. Extraction possibilities of lipids from different parts of have been studied and besides traditional solvents, so called green solvents can be used. In lipid extracts various positional and geometric isomers of fatty acids have been found and their concentrations and profiles differ amongst plant parts. Multifactor statistical analysis demonstrates the contribution of the metabolism of fatty acids in different parts of a plant. lipid extracts demonstrate high antimicrobial activity and cytotoxic activity against cancer cell lines and so plant biomass after eradication can be used to obtain substances with high application potential in the bio-pharma industry.
刺果瓜（曼登）是最危险的入侵植物之一，因含有有毒物质而声名狼藉。与此同时，从药理学应用角度来看，其植物化学，尤其是脂质方面的研究还不多。本研究旨在分析刺果瓜的脂质，特别是脂肪酸，它们的组成、代谢模式和生物活性。已经研究了从刺果瓜不同部位提取脂质的可能性，除了传统溶剂外，还可以使用所谓的绿色溶剂。在脂质提取物中发现了脂肪酸的各种位置异构体和几何异构体，它们在植物不同部位的浓度和分布有所不同。多因素统计分析表明了植物不同部位脂肪酸代谢的作用。刺果瓜脂质提取物对癌细胞系表现出高抗菌活性和细胞毒性活性，因此根除后的植物生物质可用于获取在生物制药行业具有高应用潜力的物质。
