Nuwer M R, Visscher B R, Packwood J W, Namerow N S
Ann Neurol. 1985 Jul;18(1):30-4. doi: 10.1002/ana.410180106.
Evoked potential (EP) tests were obtained in 110 neurologically normal first-degree relatives of patients with multiple sclerosis. Visual EP tests were performed in all relatives; brainstem auditory and median nerve somatosensory EP tests were performed in 67 relatives. The relatives had a mean visual EP P100 latency that was significantly longer than that for normal subjects controlled for age and gender. Asymmetries were seen in results from individual MS relatives, including interocular visual EP P100 differences of up to 14 ms, and interarm somatosensory Erb-N18 differences of up to 3.0 ms. We identified 19 pairs of patients and relatives who were HLA identical and 18 other pairs who were HLA double nonmatched. EP asymmetries were seen more often in the HLA identical siblings than in the HLA double patients, especially if they share HLA types with the patients. Since less than 2% of siblings of MS patients would be expected to eventually develop clinical MS, these small subclinical electrophysiological changes are not expected to be a sign of the future appearance of clinical MS. Clinicians should be aware not to overinterpret small EP changes in relatives of MS patients.
对110名患有多发性硬化症患者的神经功能正常的一级亲属进行了诱发电位（EP）测试。对所有亲属进行了视觉EP测试；对67名亲属进行了脑干听觉和正中神经体感EP测试。这些亲属的视觉EP P100潜伏期平均明显长于按年龄和性别匹配的正常受试者。在个别多发性硬化症亲属的测试结果中发现了不对称情况，包括两眼间视觉EP P100差异高达14毫秒，以及两臂间体感Erb - N18差异高达3.0毫秒。我们确定了19对HLA相同的患者和亲属，以及另外18对HLA完全不匹配的患者和亲属。与HLA完全不匹配的亲属相比，HLA相同的同胞中EP不对称情况更常见，尤其是当他们与患者共享HLA类型时。由于预计最终只有不到2%的多发性硬化症患者的同胞会发展为临床多发性硬化症，所以这些微小的亚临床电生理变化预计不会是未来出现临床多发性硬化症的迹象。临床医生应注意不要过度解读多发性硬化症患者亲属中微小的EP变化。
