头孢哌酮在婴儿体内的药代动力学评估。
Pharmacokinetic evaluation of cefoperazone in infants.
作者信息
Varghese M, Khan A J, Kumar K, Rosenfeld W, Schaeffer H A, Evans H E
出版信息
Antimicrob Agents Chemother. 1985 Jul;28(1):149-50. doi: 10.1128/AAC.28.1.149.
Abstract
The pharmacokinetics of cefoperazone were evaluated in 25 infants (mean age, 26 days) after intramuscular and intravenous routes of administration. The levels in blood that were achieved were severalfold higher than those required to inhibit common pathogens. The mean half-life of 240 min was one-half of that observed in 1- to 2-day-old infants but about twice that seen in adults. Further evaluation is needed to study the efficacy of the drug in infants and children.
摘要
对25名婴儿（平均年龄26天）进行了头孢哌酮肌内和静脉给药途径的药代动力学评估。所达到的血药浓度比抑制常见病原体所需的浓度高出数倍。240分钟的平均半衰期是1至2日龄婴儿观察值的一半，但约为成年人观察值的两倍。需要进一步评估以研究该药物在婴幼儿中的疗效。
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