头孢哌酮（T - 1551），一种新型半合成头孢菌素：与头孢噻吩和庆大霉素的比较。
Cefoperazone (T-1551), a new semisynthetic cephalosporin: comparison with cephalothin and gentamicin.
作者信息
Jones R N, Fuchs P C, Barry A L, Gavan T L, Sommers H M, Gerlach E H
出版信息
Antimicrob Agents Chemother. 1980 Apr;17(4):743-9. doi: 10.1128/AAC.17.4.743.
Abstract
The in vitro activity of cefoperazone (T-1551) against almost 9,000 recent clinical isolates at six institutions was tested and compared with that of cephalothin and gentamicin. The modal minimum inhibitory concentrations of cefoperazone were 16- and 4-fold less than those of cephalothin and gentamicin, respectively, against 5,503 strains of Enterobacteriaceae. Species normally resistant to cephalothin, such as indole-positive protease and enterobacters, were almost universally susceptible to cefoperazone. Cefoperazone demonstrated activity comparable to gentamicin against Pseudomonas aeruginosa and other pseudomonads.
摘要
对头孢哌酮（T - 1551）在六个机构针对近9000株近期临床分离菌株的体外活性进行了测试，并与头孢噻吩和庆大霉素的活性进行了比较。针对5503株肠杆菌科菌株，头孢哌酮的最低抑菌浓度中值分别比头孢噻吩和庆大霉素低16倍和4倍。通常对头孢噻吩耐药的菌种，如吲哚阳性变形杆菌和肠杆菌，几乎对头孢哌酮普遍敏感。头孢哌酮对铜绿假单胞菌和其他假单胞菌的活性与庆大霉素相当。
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