Liu Annan, Li Jianwen, Qu Wenrui, Yang Boyu, Li Xingchen, Li Lei, Liang Hao, Whittaker Andrew K, Wang Kexin, Wang Ze, Guo Wenlai, Lin Quan
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China.
Department of Hand Surgery, The Second Hospital of Jilin University, Changchun 130041, China; Gastroenteric Medicine and Digestive Endoscopy Center, The Second Hospital of Jilin University, Changchun 130041, China.
J Colloid Interface Sci. 2025 Oct 15;696:137867. doi: 10.1016/j.jcis.2025.137867. Epub 2025 May 11.
Bacterial infection and excessive inflammation are key factors contributing to the difficulty of healing diabetic wounds. Therefore, the development of a wound dressing that effectively fights bacterial infections, and addresses the challenges of long-term inflammation and repair difficulties is essential in clinical practice. Herein, a multifunctional ZnAuNDs@hydrogel (ZAN@HG) nanocomposite wound dressing capable of releasing zinc ions, and enhanced fluorescent and photothermal performance was developed to promote methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wounds healing. The nanocomposite hydrogel also indicates in real-time with dressing replacement is required. The synergistic mechanism of enhanced-photothermal therapy (PTT) and zinc supplementation of ZAN@HG nanocomposite, can efficiently accelerate wound healing. Its excellent antibacterial and anti-inflammatory properties, along with the ability to regulate cell migration, promote collagen deposition, and enhance angiogenesis, make it an ideal adjunct for diabetic wound treatment. Moreover, the fluorescent nanocomposite can serve as a "dashboard" for intelligent self-monitoring, indicating the residual level of therapeutic agents in the dressing. The variation in fluorescence intensity is visually discernible, providing medical staff with a clear visual cue of the need for dressing replacement, thus effectively mitigating secondary wound damage. This work provides a promising strategy for the treatment of clinical diabetic wounds, and the intelligent self-monitoring of residual drug in the dressing.
细菌感染和过度炎症是导致糖尿病伤口愈合困难的关键因素。因此，开发一种能有效对抗细菌感染、应对长期炎症和修复困难挑战的伤口敷料在临床实践中至关重要。在此，开发了一种多功能的ZnAuNDs@水凝胶（ZAN@HG）纳米复合伤口敷料，其能够释放锌离子，并具有增强的荧光和光热性能，以促进耐甲氧西林金黄色葡萄球菌（MRSA）感染的糖尿病伤口愈合。该纳米复合水凝胶还能实时指示是否需要更换敷料。ZAN@HG纳米复合材料增强光热疗法（PTT）和补锌的协同机制能够有效加速伤口愈合。其出色的抗菌和抗炎特性，以及调节细胞迁移、促进胶原蛋白沉积和增强血管生成的能力，使其成为糖尿病伤口治疗的理想辅助手段。此外，荧光纳米复合材料可作为智能自我监测的“仪表盘”，指示敷料中治疗剂的残留水平。荧光强度的变化肉眼可见，为医护人员提供了更换敷料需求的清晰视觉提示，从而有效减轻伤口二次损伤。这项工作为临床糖尿病伤口的治疗以及敷料中残留药物的智能自我监测提供了一种有前景的策略。
