Rowntree S, Cogswell J J, Platts-Mills T A, Mitchell E B
Arch Dis Child. 1985 Aug;60(8):727-35. doi: 10.1136/adc.60.8.727.
In a prospective study of 92 children with at least one atopic parent, the development of the specific antibody responses to food and inhalant allergens during the first 5 years of life were assessed. By the radioallergosorbent test egg specific IgE antibody occurred in about 30% of the children with the mean peak concentration at 12 months. By the second year the prevalence of this antibody had increased whereas the mean concentration had decreased. Milk specific IgE antibody could not be shown in any subject, including four whose skin tests yielded positive results. Food specific IgG antibody was noted by antigen binding radioimmunoassays at 3 months in most children. These responses had peaked and began to fall by the fifth year. In contrast few children had detectable IgE or IgG antibody to inhalant allergens before the first 2 years of life. Both the concentration and prevalence of specific antibody, however, increased from the second to the fifth year and was greater in children whose skin tests yielded positive results. Breast feeding was associated with an increase in the prevalence of positive results from skin tests but was not associated with detectable IgE antibody to both food proteins, a lower concentration of IgG antibody to cows' milk, and was not associated with protection against the development of disease. A high level of exposure to dust mite was associated with an increased prevalence of positive results from skin tests to dust mite and appreciably higher antibody concentration. This study indicates differences in the humoral responses to food and inhalant allergens. Environmental factors appear to influence the development of these responses.
在一项针对92名至少有一位特应性父母的儿童的前瞻性研究中，评估了他们在生命的前5年中对食物和吸入性过敏原的特异性抗体反应的发展情况。通过放射变应原吸附试验，约30%的儿童出现了鸡蛋特异性IgE抗体，平均峰值浓度出现在12个月时。到第二年，这种抗体的患病率增加，而平均浓度下降。在任何受试者中均未检测到牛奶特异性IgE抗体，包括4名皮肤试验呈阳性的儿童。大多数儿童在3个月时通过抗原结合放射免疫测定法检测到食物特异性IgG抗体。这些反应在第五年达到峰值并开始下降。相比之下，在生命的前2年之前，很少有儿童对吸入性过敏原检测到IgE或IgG抗体。然而，从第二年到第五年，特异性抗体的浓度和患病率均有所增加，且在皮肤试验呈阳性的儿童中更高。母乳喂养与皮肤试验阳性结果的患病率增加有关，但与对两种食物蛋白的可检测IgE抗体、较低浓度的牛奶IgG抗体无关，也与预防疾病的发生无关。高暴露于尘螨与尘螨皮肤试验阳性结果的患病率增加以及明显更高的抗体浓度有关。这项研究表明了对食物和吸入性过敏原的体液反应存在差异。环境因素似乎会影响这些反应的发展。
