Cogswell J J, Halliday D F, Alexander J R
Br Med J (Clin Res Ed). 1982 Apr 3;284(6321):1011-3. doi: 10.1136/bmj.284.6321.1011.
Ninety-two infants, each of whom had one parent with asthma or hay fever, were followed up from birth to age of 1 year and 72 to the age of three years. During the first year of life respiratory symptoms, eczema, and respiratory viral infections were all reported. Within the first year 24 babies developed eczema; 28 had a wheal of 1 mm in diameter or more on prick skin testing with cutaneous allergens. Forty-three children had one or both of these characteristics and formed an atopic subgroup; by the same criteria, 49 children were non-atopic. The number of respiratory infections in the two groups was not significantly different; similar viruses were isolated from both groups. These viruses were associated with both upper and lower respiratory tract infections. Wheezing was a clinical feature in 12 children during lower respiratory tract infections. Of these babies six were atopic in the first year of life. Of the six non-atopic babies, one had eczema in the second year and five children developed raised total serum IgE values within the 3 years.
92名婴儿，他们每人都有一位患有哮喘或花粉热的父母，从出生起被随访至1岁，72名婴儿被随访至3岁。在生命的第一年，均记录到呼吸道症状、湿疹和呼吸道病毒感染情况。在第一年里，24名婴儿出现了湿疹；28名婴儿在使用皮肤过敏原进行点刺皮肤试验时出现了直径1毫米或更大的风团。43名儿童具有上述一种或两种特征，形成了一个特应性亚组；按照相同标准，49名儿童为非特应性。两组呼吸道感染的数量没有显著差异；两组均分离出相似的病毒。这些病毒与上、下呼吸道感染均有关。12名儿童在发生下呼吸道感染时有喘息这一临床特征。在这些婴儿中，6名在生命的第一年为特应性。在6名非特应性婴儿中，1名在第二年出现了湿疹，5名儿童在3年内总血清IgE值升高。
