Sziklai I, Ribári O
Arch Otorhinolaryngol. 1985;242(1):67-70. doi: 10.1007/BF00464409.
We studied the effect of 7-isopropoxy-isoflavone (Ipriflavone) on the collagen synthesizing activity in human otosclerotic auditory ossicle samples from whole organ cultures during incubation for 96 h, and compared this effect with that found in normal meatal cortical bone. Ipriflavone led to a dose-dependent increase in the collagen synthesizing activity in both the healthy and the otosclerotic bone samples. At the highest Ipriflavone concentration used (50 microM), collagen synthesis increased 6-fold in the cortical bone and 9-fold in the otosclerotic bone, as compared with untreated controls. These findings indicate that the otosclerotic bone cavities are filled in vitro with organic matrix.
我们研究了7-异丙氧基异黄酮（依普黄酮）对人耳硬化听觉小骨样本在全器官培养96小时孵育期间胶原合成活性的影响，并将此效应与正常耳道皮质骨中的效应进行比较。依普黄酮导致健康和耳硬化骨样本中的胶原合成活性呈剂量依赖性增加。与未处理的对照组相比，在所用的最高依普黄酮浓度（50微摩尔）下，皮质骨中的胶原合成增加了6倍，耳硬化骨中的胶原合成增加了9倍。这些发现表明，耳硬化骨腔在体外被有机基质填充。
