OBJECTIVE: Exploring the construction and effectiveness of a inter-disciplinary undergraduate nursing talent cultivation model in the context of"great health". METHODS: Adopting cluster sampling method, undergraduate nursing students enrolled in 2019 and 2020 were selected as the research subjects. The students who entered the school in 2019 were selected as the control group, who was cultivated according to"applied talent"cultivation model, Correspondingly, the students who entered the school in 2020 were selected as the experimental group, who was cultivated according to"inter-disciplinary talent"cultivation model. The practical effects of the two cultivation models were evaluated by stages: investigating students' innovation ability and scientific and technological readiness before clinical intership; investigating the satisfaction of the employer, service recipients, and clinical teacher with the students at the end of the clinical internship; Counting the total credits and average grades of compulsory courses for students at graduation. RESULTS: The innovation ability score and scientific and technology readiness score of the experimental group students were higher than those of the control group students before the internship; At the end of the clinical internship, the satisfaction scores of the employer, service recipients, and clinical teacher of the experimental group students were higher than those of the control group students; At graduation, the total credits and average scores of compulsory courses of the experimental group students were higher than those of the control group students, and the differences were statistically significant (P < 0.05). CONCLUSION: The "inter-disciplinary talent" cultivation model is conducive to improving students' innovation ability、scientific and technological readiness、social satisfaction, and academic performance.