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48小时内进行早期手术是否能改善老年髋部骨折的临床结局?一项针对1776例髋部骨折的配对队列研究。

Does early surgery within 48 hours improve clinical outcomes in elderly hip fractures? A matched cohort study of 1776 hip fractures.

作者信息

Chu Zachary, Ng Julia Poh Hwee, Chua Tjun Huat Ivan, Ho Sean Wei Loong

机构信息

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Department of Orthopedic Surgery, Tan Tock Seng Hospital, Singapore, Singapore.

出版信息

Eur J Orthop Surg Traumatol. 2025 May 18;35(1):201. doi: 10.1007/s00590-025-04324-2.

Abstract

PURPOSE

The aim of this study was to determine if a delay to surgery of more than 48 h was associated with poorer functional outcomes and increased 1-year mortality rates for elderly hip fractures.

METHODS

A retrospective review of surgically treated elderly (≥ 60 years old) hip fracture patients in a single institution was conducted. Patients were divided into 2 groups depending on hours from admission to surgery: Group 1 ( ≤ 48 h) and Group 2 (> 48 h); these groups were 1:1 matched for the initial Modified Barthel's Index (MBI) and Charlson Comorbidity Index (CCI).

RESULTS

2562 patients were eligible for the study. The cut-point value in a receiver operating curve analysis for 12-month MBI against time to surgery was not robust enough to determine an optimal time for surgery. Group 1 (n = 888) had significantly better MBI scores at 6-months [mean 78.7 (± 19.9) vs. mean 75.5 (± 20.6)] and 1-year [mean 80.4 (± 20.1) vs. mean 76.9 (± 22.3)] (p < 0.001). This difference in MBI scores between the groups did not meet the minimal clinically important difference of 10  points. There was no significant difference in 1-year mortality (3.7% vs. 4.4%) (p = 0.427). Delayed surgery past 48 h significantly increased the risk of post-operative complications. (Urinary tract infection, acute retention of urine and pneumonia) (p < 0.001).

CONCLUSION

Delayed surgery for elderly hip fractures after 48 h increases the risk of acute post-operative complications. There is no increase in 1-year mortality and no clinically important deterioration of MBI if operated on after 48 h.

LEVEL OF EVIDENCE

III.

摘要

目的

本研究旨在确定老年髋部骨折手术延迟超过48小时是否与较差的功能结局及1年死亡率增加相关。

方法

对一家机构中接受手术治疗的老年(≥60岁)髋部骨折患者进行回顾性研究。根据入院至手术的时长将患者分为两组:第1组(≤48小时)和第2组(>48小时);这两组在初始改良巴氏指数(MBI)和查尔森合并症指数(CCI)方面进行1:1匹配。

结果

2562例患者符合研究条件。在针对12个月MBI与手术时间的受试者工作特征曲线分析中,切点值不够稳健,无法确定最佳手术时间。第1组(n = 888)在6个月时的MBI评分显著更高[平均78.7(±19.9)对平均75.5(±20.6)]以及1年时[平均80.4(±20.1)对平均76.9(±22.3)](p < 0.001)。两组间MBI评分的差异未达到最小临床重要差异10分。1年死亡率无显著差异(3.7%对4.4%)(p = 0.427)。手术延迟超过48小时显著增加术后并发症风险。(尿路感染、急性尿潴留和肺炎)(p < 0.001)。

结论

老年髋部骨折48小时后延迟手术会增加急性术后并发症风险。48小时后手术,1年死亡率无增加,MBI也无临床重要性恶化。

证据级别

III级。

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