Val'dman A V, Voronina T A, Smirnov L D, Tilekeeva U M, Diumaev K M
Biull Eksp Biol Med. 1985 Jan;99(1):60-2.
Experiments on mice and rats were made to study the effect of inhibitors-antioxidants (3-hydroxypyridine derivatives) on the central nervous system. It was established that 3-hydroxypyridine derivatives (50 to 200 mg/kg) possess a broad spectrum of psychotropic effects. They cause normalization of behavior in conflict situations, exert an antiaggressive and anticonvulsant action (antagonism with corazol), are capable of potentiating the hypnotic effect of barbiturates, and of suppressing the animals' motor activity if given in high doses. Most compounds under study have antihypoxic and antiamnestic effects.
开展了对小鼠和大鼠的实验，以研究抑制剂 - 抗氧化剂（3 - 羟基吡啶衍生物）对中枢神经系统的影响。已确定3 - 羟基吡啶衍生物（50至200毫克/千克）具有广泛的精神药理作用。它们可使冲突情境中的行为恢复正常，发挥抗攻击和抗惊厥作用（与戊四氮拮抗），能够增强巴比妥类药物的催眠效果，且高剂量给药时可抑制动物的运动活动。大多数所研究的化合物具有抗缺氧和抗遗忘作用。
