Pischart Kittithach, Khemworapong Khemanat, Chaopotong Pattama, Achariyapota Vuthinun
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Bangkok, Thailand.
Obstet Gynecol Int. 2025 May 10;2025:2918759. doi: 10.1155/ogi/2918759. eCollection 2025.
Malnutrition is a major concern in patients with advanced ovarian cancer, and this condition may be associated with poor treatment outcomes. This study aims to estimate the prevalence of malnutrition in advanced ovarian cancer patients and investigate its impact on both surgical and oncological outcomes. This retrospective study included 290 advanced-stage ovarian cancer patients (FIGO stage III-IV) who were not diagnosed with malnutrition. The median follow-up time was 36 months. Malnutrition was defined using the Geriatric Nutritional Risk Index (GNRI). Retrospective data on patient characteristics, treatment complications, and outcomes were recorded. Statistical analyses were performed using IBM SPSS Statistics for Windows (Version 26.0; IBM Corp., Armonk, NY, USA). This study found that 137 of 290 patients (47.2%) had malnutrition. Anemia and chronic kidney disease (CKD) were frequently observed alongside malnutrition. Malnutrition impacts both surgical and oncological outcomes, including the rate of optimal debulking surgeries (35.8% in the malnourished group and 62.7% in the well-nourished group, < 0.005) and the median length of hospital stay (10 days in the malnourished group and 7 days in the well-nourished group, < 0.005). Additionally, well-nourished patients had a significant higher overall survival rate (43 months) compared to malnourished patients (30 months). Malnutrition is common among patients with advanced ovarian cancer and is associated with a lower rate of optimal surgery, longer hospital stays, and reduced overall survival rates.
营养不良是晚期卵巢癌患者的一个主要问题，这种情况可能与治疗效果不佳有关。本研究旨在评估晚期卵巢癌患者中营养不良的患病率，并调查其对手术和肿瘤学结局的影响。这项回顾性研究纳入了290例未被诊断为营养不良的晚期卵巢癌患者（国际妇产科联盟（FIGO）分期为III-IV期）。中位随访时间为36个月。使用老年营养风险指数（GNRI）定义营养不良。记录了患者特征、治疗并发症和结局的回顾性数据。使用IBM SPSS Statistics for Windows（版本26.0；IBM公司，美国纽约州阿蒙克）进行统计分析。本研究发现，290例患者中有137例（47.2%）存在营养不良。贫血和慢性肾脏病（CKD）常与营养不良同时出现。营养不良会影响手术和肿瘤学结局，包括最佳肿瘤细胞减灭术的比例（营养不良组为35.8%，营养良好组为62.7%，<0.005）和中位住院时间（营养不良组为10天，营养良好组为7天，<0.005）。此外，营养良好的患者的总生存率（43个月）显著高于营养不良的患者（30个月）。营养不良在晚期卵巢癌患者中很常见，并且与最佳手术比例较低、住院时间延长和总生存率降低有关。
