Azmin Muhammad Rayza, Habibie Habibie, Filmaharani Filmaharani, Roosevelt Alfreds, Nurhidayah Anggun, Pratama Muhammad Rasul, Hardiyanti Widya, Latada Nadila Pratiwi, Mudjahid Mukarram, Yuliana Dewi, Nainu Firzan
Postgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar 90245, Indonesia.
Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar 90245, Indonesia.
ACS Omega. 2025 Apr 29;10(18):18622-18628. doi: 10.1021/acsomega.4c11509. eCollection 2025 May 13.
Diabetes mellitus (DM), particularly type 2 diabetes mellitus (T2DM), is a global health challenge marked by chronic hyperglycemia and inflammation, which contributes to both metabolic dysregulation and associated complications. Inflammation exacerbates T2DM by activating immune signaling pathways and promoting insulin resistance. This study aims to investigate the interplay between hyperglycemia and inflammation and to explore the therapeutic potential of aspirin in mitigating these processes using as a model organism. We utilized the strain, which exhibits dysregulated immune responses due to the loss of the gene, leading to a phenotype resembling human autoinflammatory conditions. Larvae of the were fed a high-sucrose diet to induce increased glucose levels, mimicking the metabolic disturbances of T2DM. Aspirin, at different concentrations, was administered to assess its effects on high glucose level-induced inflammation. The results demonstrated that aspirin significantly improved hemolymph glucose levels, larval size, weight, and development. Additionally, aspirin enhanced larval mobility and reduced glucose level-associated immune dysfunction, as evidenced by changes in the expression of key immune and insulin-related genes. These findings highlight the utility of as an effective and cost-efficient model to investigate the molecular mechanisms of T2DM and inflammation. The study also provides preliminary evidence for the potential of aspirin as an anti-inflammatory agent to modulate glucose levels and inflammation in T2DM, offering a promising avenue for therapeutic development.
糖尿病（DM），尤其是2型糖尿病（T2DM），是一项全球性的健康挑战，其特征为慢性高血糖和炎症，这会导致代谢失调及相关并发症。炎症通过激活免疫信号通路和促进胰岛素抵抗来加重T2DM。本研究旨在利用 作为模式生物，研究高血糖与炎症之间的相互作用，并探索阿司匹林在减轻这些过程中的治疗潜力。我们使用了 品系，该品系由于 基因缺失而表现出免疫反应失调，导致出现类似于人类自身炎症性疾病的表型。给 的幼虫喂食高糖饮食以诱导血糖水平升高，模拟T2DM的代谢紊乱。给予不同浓度的阿司匹林以评估其对高血糖水平诱导的炎症的影响。结果表明，阿司匹林显著改善了血淋巴葡萄糖水平、幼虫大小、体重和发育。此外，阿司匹林增强了幼虫的活动能力，并减少了与葡萄糖水平相关的免疫功能障碍，关键免疫和胰岛素相关基因表达的变化证明了这一点。这些发现突出了 作为研究T2DM和炎症分子机制的有效且经济高效的模型的实用性。该研究还为阿司匹林作为一种抗炎剂调节T2DM中的葡萄糖水平和炎症的潜力提供了初步证据，为治疗开发提供了一条有前景的途径。
