Department of Molecular Biology and Biochemistry, Centre for Cell Biology, Development and Disease, Simon Fraser University, 8888 University Drive, Burnaby, BC, CanadaV5A 1S6.
Dis Model Mech. 2022 Mar 1;15(3). doi: 10.1242/dmm.049549. Epub 2022 Mar 29.
Six years ago, DMM launched a subject collection called 'Drosophila as a Disease Model'. This collection features Review-type articles and original research that highlight the power of Drosophila research in many aspects of human disease modeling. In the ensuing years, Drosophila research has further expanded to capitalize on genome editing, development of resources, and further interest in studying rare disease mechanisms. In the current issue of DMM, we again highlight the versatility, breadth, and scope of Drosophila research in human disease modeling and translational medicine. While many researchers have embraced the power of the fly, many more could still be encouraged to appreciate the strengths of Drosophila and how such research can integrate across species in a multi-pronged approach. Only when we truly acknowledge that all models contribute to our understanding of human biology, can we take advantage of the scope of current research endeavors.
六年前，DMM 推出了一个名为“果蝇作为疾病模型”的专题集。该专题集收录了综述类文章和原始研究，强调了果蝇研究在人类疾病建模的许多方面的强大功能。在随后的几年里，果蝇研究进一步扩展，利用基因组编辑、资源开发以及对研究罕见疾病机制的进一步兴趣。在本期的 DMM 中，我们再次强调了果蝇在人类疾病建模和转化医学中的多功能性、广度和范围。虽然许多研究人员已经接受了果蝇的强大功能，但仍有更多的人可以被鼓励去欣赏果蝇的优势，以及这种研究如何以多管齐下的方式在物种间进行整合。只有当我们真正认识到所有模型都有助于我们理解人类生物学时，我们才能充分利用当前研究工作的范围。
