Dong Jialong, Huang Liufang, Wang Chuchu, Luo Xinyi, Wei Jin, Abuduxukuer KaiweiSa, Luo Jianfeng, Zhou Yifan, Peng Qing
Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Front Nutr. 2025 May 2;12:1527029. doi: 10.3389/fnut.2025.1527029. eCollection 2025.
To investigate the associations between urinary enterolignans concentration and oral probiotic ingestion using nationally representative data from the United States population.
We analyzed dietary recall data and urinary enterolignans concentrations from 12,358 eligible participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2010. Linear regression models with comprehensive covariate adjustments were employed to assess associations, accounting for demographic, socioeconomic, health status, and lifestyle factors.
Participants with dietary probiotic ingestion had higher urinary concentrations of enterolignans, and probiotic ingestion showed robust and profound positive correlations with enterolignans after fully adjusted with multiple confounders (all values<0.05). Frequent probiotic consumption exerts a more profound and positive impact on enterolignans concentrations than Infrequent probiotic consumption, according to correlation coefficient values in both univariate and multivariate analyses.
Dietary probiotic consumption was significantly associated with elevated urinary enterolignans concentrations in the U.S. population, with high-frequency intake demonstrating a stronger dose-response relationship compared to low-frequency consumption.
利用来自美国人群的具有全国代表性的数据，研究尿中肠内酯浓度与口服益生菌摄入之间的关联。
我们分析了1999 - 2010年全国健康和营养检查调查（NHANES）中12358名符合条件的参与者的饮食回忆数据和尿中肠内酯浓度。采用具有全面协变量调整的线性回归模型来评估关联，同时考虑人口统计学、社会经济、健康状况和生活方式因素。
摄入膳食益生菌的参与者尿中肠内酯浓度较高，在对多个混杂因素进行完全调整后，益生菌摄入与肠内酯呈强烈且显著的正相关（所有P值<0.05）。根据单变量和多变量分析中的相关系数值，频繁摄入益生菌比不频繁摄入益生菌对肠内酯浓度有更显著的正向影响。
在美国人群中，膳食益生菌摄入与尿中肠内酯浓度升高显著相关，与低频摄入相比，高频摄入显示出更强的剂量反应关系。
