Cuccurullo F, Abate G, Tomassetti V, Mezzetti A, Masi M, Rosini R, Lenzi S
Arch Mal Coeur Vaiss. 1977 Jan;70(1):25-32.
5 patients with angina had their threshold for angina evaluated by atrial pacing and by stimulation with catecholamine (dopamine). The authors then studied the metabolic changes induced by the two types of anginogenic load (AP and D-test) applied successively, and compared them with the post-ergometry ECG changes (lowering of the ST segment by at least 2 mm) and the findings on coronary arteriography (complete obstruction of at least 75% stenosis of a major branch vessel). The metabolic measurements were controlled against those of 5 normal subjects after standard ergometry. In the patients with angina, the AP test led to a constantly negative value for %. L. By contrast, the values of D(a-v)c and % O2 which were reduced in the normals, as indirect evidence of an increased coronary flow, remained practically static. During the dopamine infusion, although the % L was reduced, it remained essentially positive, while the D(a-v)c and % O2 were consistantly lowered.
5名心绞痛患者通过心房起搏和儿茶酚胺（多巴胺）刺激来评估其心绞痛阈值。作者随后研究了先后施加的两种致心绞痛负荷（心房起搏和多巴胺试验）所诱发的代谢变化，并将其与运动后心电图变化（ST段压低至少2毫米）以及冠状动脉造影结果（主要分支血管至少75%狭窄的完全阻塞）进行比较。代谢测量结果与5名正常受试者在标准运动试验后的测量结果进行对照。在心绞痛患者中，心房起搏试验导致%L持续为负值。相比之下，正常情况下降低的D(a-v)c和%O2值，作为冠状动脉血流增加的间接证据，实际上保持不变。在多巴胺输注期间，尽管%L降低，但仍基本为正值，而D(a-v)c和%O2持续降低。
