Andĕl M, Brodan V, Fabián J, Veselková A
Cor Vasa. 1982;24(4):277-81.
Nine patients with the angina pectoris syndrome in the absence of a history of demonstrable myocardial infarction were examined twice at rest and during cardiac pacing at 13-min intervals. Glucagon (0.5 mg/50 ml saline) was applied before the second examination. The authors investigated the differences of lactate (La) and lactate-pyruvate ratio (La:Py) between arterial blood and coronary sinus (a-cs diff) and the values of serum transaminases and glycaemia. A negative La and/or La:Py a-cs diff during or after pacing was interpreted as a positive qualitative sign of induced acute myocardial ischaemia. Application of glucagon on the second cardiac pacing led to worsening of the metabolic situation in 71% of patients; none of the patients showed improvement. The La:Py a-cs diff after glucagon was negative in all patients.
对9例无明显心肌梗死病史的心绞痛综合征患者，在静息状态下及每隔13分钟心脏起搏期间进行了两次检查。在第二次检查前应用了胰高血糖素（0.5mg/50ml生理盐水）。作者研究了动脉血与冠状窦之间乳酸（La）和乳酸-丙酮酸比值（La:Py）的差异（a-cs差值）以及血清转氨酶和血糖值。起搏期间或之后出现负的La和/或La:Py a-cs差值被解释为诱导急性心肌缺血的阳性定性指标。在第二次心脏起搏时应用胰高血糖素导致71%的患者代谢状况恶化；所有患者均未显示改善。所有患者在应用胰高血糖素后La:Py a-cs差值均为阴性。
