Hansen Stefan, Kansy Benjamin, Brandau Sven, Epple Matthias, Lang Stephan
Hals-Nasen-Ohrenpraxis am Waldweg, Waldweg 1, 37073, Göttingen, Deutschland.
Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Essen, Universität Duisburg-Essen, Duisburg-Essen, Deutschland.
HNO. 2025 May 19. doi: 10.1007/s00106-025-01633-0.
The rapid expansion and application of nanoparticles in medicine has meanwhile contributed to a large number of experimental and clinical studies, especially in cancer research. Numerous different fields within nanomedicine have now become established more clearly. These are based on the one hand on the properties of different types of nanoparticles (chemical, physical, and biological) and on the other hand on the possible specific applications such as drug carrier, radioenhancer, in vivo monitoring of drug distribution within the tumor, or tumor-specific immune-modulating effects. Nanoparticles can also be functionalized by multiple properties potentiating their intrinsic antitumoral effects, such as coupling of antibodies to address target tissue or coupling to chemotherapeutic agents. In this work, an up-to-date overview of the developments and applications related to nanoparticles in head and neck cancer is given.
与此同时，纳米颗粒在医学领域的迅速扩展和应用推动了大量实验和临床研究，尤其是在癌症研究方面。如今，纳米医学内众多不同领域已变得更加清晰明确。这些领域一方面基于不同类型纳米颗粒的特性（化学、物理和生物学特性），另一方面基于可能的特定应用，如药物载体、放射增强剂、肿瘤内药物分布的体内监测或肿瘤特异性免疫调节作用。纳米颗粒还可通过多种特性进行功能化，增强其内在抗肿瘤作用，例如将抗体偶联以靶向目标组织或与化疗药物偶联。在这项工作中，给出了与纳米颗粒在头颈癌中的发展和应用相关的最新综述。
