多功能金纳米平台的构建及其在口腔癌细胞联合化疗-光热治疗中的应用
Development of a multifunctional gold nanoplatform for combined chemo-photothermal therapy against oral cancer.
机构信息
Department of Oral & Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, PR China.
Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
出版信息
Nanomedicine (Lond). 2020 Mar;15(7):661-676. doi: 10.2217/nnm-2019-0415. Epub 2020 Mar 6.
To design and fabricate a multifunctional drug-delivery nanoplatform for oral cancer therapy. Polyethylene glycol-stabilized, PDPN antibody (PDPN Ab)- and doxorubicin (DOX)-conjugated gold nanoparticles (AuNPs) were prepared and evaluated for their cytotoxicity and antitumor efficacy in both chemotherapy and photothermal therapy. The obtained (PDPN Ab)-AuNP-DOX system presents low toxicity, a high drug loading capacity and cellular uptake efficiency. Both and experiments demonstrate that (PDPN Ab)-AuNP-DOX has enhanced antitumor efficacy. Treatment with (PDPN Ab)-AuNP-DOX combined with laser irradiation exhibits superior antitumor effects. This (PDPN Ab)-AuNP-DOX system may be used as a versatile drug-delivery nanoplatform for targeted and combined chemo-photothermal therapy against oral cancer.
设计并构建一种多功能药物输送纳米平台，用于口腔癌治疗。制备了聚乙二醇稳定的、PDPN 抗体（PDPN Ab）和阿霉素（DOX）偶联的金纳米颗粒（AuNPs），并评估了它们在化疗和光热治疗中的细胞毒性和抗肿瘤功效。所得到的（PDPN Ab）-AuNP-DOX 系统具有低毒性、高载药能力和细胞摄取效率。和 实验均表明（PDPN Ab）-AuNP-DOX 具有增强的抗肿瘤功效。与激光照射联合使用（PDPN Ab）-AuNP-DOX 治疗表现出优异的抗肿瘤效果。该（PDPN Ab）-AuNP-DOX 系统可用作一种通用的药物输送纳米平台，用于针对口腔癌的靶向和联合化疗-光热治疗。
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