Wolff S, James T L, Young G B, Margulis A R, Bodycote J, Afzal V
Radiology. 1985 Apr;155(1):163-5. doi: 10.1148/radiology.155.1.4038809.
Human lymphocytes and Chinese hamster ovary (CHO) cells in culture were exposed for 12 1/2 hours to a magnetic resonance imaging apparatus with a 2.35-Tesla magnet and 100-MHz radio frequency emission. The cells were examined for cytogenetic damage manifested either as chromosome aberrations or sister chromatid exchanges (SCEs), which constitute very sensitive measures of genetic and cellular damage. In either unstimulated or stimulated human lymphocytes, as well as in exponentially growing CHO cells, no increase in either chromosome aberrations or SCEs was found as a result of exposure to these MR conditions. The data indicate that long-term exposure to MR imaging conditions far exceeding those to be found in the clinical situation does not cause cytogenetic damage.
将培养的人类淋巴细胞和中国仓鼠卵巢（CHO）细胞置于一台带有2.35特斯拉磁体和100兆赫射频发射的磁共振成像设备中，暴露12个半小时。检测细胞的细胞遗传学损伤，其表现为染色体畸变或姐妹染色单体交换（SCEs），这是遗传和细胞损伤的非常敏感的指标。无论是未受刺激还是受刺激的人类淋巴细胞，以及指数生长的CHO细胞，暴露于这些磁共振条件下，染色体畸变或SCEs均未增加。数据表明，长期暴露于远远超过临床情况的磁共振成像条件下不会导致细胞遗传学损伤。
