Xu L T, Sun C F, Wang Y E, Song H Z
Ann Thorac Surg. 1985 Mar;39(3):257-9. doi: 10.1016/s0003-4975(10)62590-8.
A regimen of multiple intermittent intensive doses of chemotherapy (chiefly 5-fluorouracil) was used in a series of 806 women with choriocarcinoma and malignant mole. The rate of complete remission of choriocarcinoma was 78.6%, and approximately 85% of the patients survived for more than 5 years. From 1962 through 1982, pulmonary metastatic choriocarcinoma was found to be resistant to chemotherapeutic agents in 43 of these patients; they subsequently underwent lung resection. There were no postoperative deaths, and the 5-year survival was 50%. These are relatively good results for patients with long-standing and widely disseminated choriocarcinoma. Human chorionic gonadotropin titer in urine and blood and variations of lung shadows are important criteria in selecting candidates for lung resection. For preservation of lung function, simple lobectomy is the first choice. Better long-term survival was obtained in patients who had a solitary lung lesion on admission without other major organ metastases and in those in whom the lung lesion was well encapsulated and became necrotic after chemotherapy.
对806例绒毛膜癌和恶性葡萄胎女性患者采用了多次间歇性强化化疗方案（主要是5-氟尿嘧啶）。绒毛膜癌的完全缓解率为78.6%，约85%的患者存活超过5年。1962年至1982年期间，在这些患者中有43例肺转移性绒毛膜癌被发现对化疗药物耐药；他们随后接受了肺切除术。术后无死亡病例，5年生存率为50%。对于长期存在且广泛播散的绒毛膜癌患者来说，这些结果相对较好。尿和血中的人绒毛膜促性腺激素水平以及肺部阴影的变化是选择肺切除患者的重要标准。为了保留肺功能，单纯肺叶切除术是首选。入院时肺部有孤立性病变且无其他主要器官转移的患者，以及肺部病变包膜完整且化疗后发生坏死的患者，其长期生存率更高。
