Department of Chemical Engineering and Sustainability, International Islamic University Malaysia, P.O. Box 10, 50728 Kuala Lumpur, Malaysia.
Department of Chemical Engineering and Sustainability, International Islamic University Malaysia, P.O. Box 10, 50728 Kuala Lumpur, Malaysia.
Int J Biol Macromol. 2024 Apr;265(Pt 1):130858. doi: 10.1016/j.ijbiomac.2024.130858. Epub 2024 Mar 13.
Electrospinning has been acknowledged as an efficient technique for the fabrication of continuous nanofibers from polymeric based materials such as polyvinyl alcohol (PVA), cellulose acetate (CA), chitin nanocrystals and others. These nanofibers exhibit chemical and mechanical stability, high porosity, functionality, high surface area and one-dimensional orientation which make it extremely beneficial in industrial application. In recent years, research on chitin - a biopolymer derived from crustacean and fungal cell wall - had gained interest due to its unique structural arrangement, excellent physical and chemical properties, in which make it biodegradable, non-toxic and biocompatible. Chitin has been widely utilized in various applications such as wound dressings, drug delivery, tissue engineering, membranes, food packaging and others. However, chitin is insoluble in most solvents due to its highly crystalline structure. An appropriate solvent system is required for dissolving chitin to maximize its application and produce a fine and smooth electrospun nanofiber. This review focuses on the preparation of chitin polymer solution through dissolution process using different types of solvent system for electrospinning process. The effect of processing parameters also discussed by highlighting some representative examples. Finally, the perspectives are presented regarding the current application of electrospun chitin nanofibers in selected fields.
静电纺丝已被公认为是一种从基于聚合物的材料（如聚乙烯醇（PVA）、醋酸纤维素（CA）、壳聚糖纳米晶体等）制备连续纳米纤维的有效技术。这些纳米纤维具有化学和机械稳定性、高孔隙率、功能性、高表面积和一维取向，这使得它们在工业应用中极具优势。近年来，由于其独特的结构排列、优异的物理和化学性质，使得其具有可生物降解性、无毒性和生物相容性，来源于甲壳动物和真菌细胞壁的生物聚合物壳聚糖的研究引起了人们的兴趣。壳聚糖已广泛应用于各种领域，如伤口敷料、药物输送、组织工程、膜、食品包装等。然而，由于其高度结晶的结构，壳聚糖在大多数溶剂中都不溶。需要适当的溶剂体系来溶解壳聚糖，以最大限度地发挥其应用，并制备出精细、光滑的静电纺纳米纤维。本综述重点介绍了通过使用不同类型的溶剂体系进行溶解过程来制备壳聚糖聚合物溶液，用于静电纺丝过程。还通过突出一些代表性的例子讨论了加工参数的影响。最后，就静电纺丝壳聚糖纳米纤维在选定领域的当前应用提出了展望。
