• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice.

作者信息

Naganuma A, Satoh M, Koyama Y, Imura N

出版信息

Toxicol Lett. 1985 Feb-Mar;24(2-3):203-7. doi: 10.1016/0378-4274(85)90058-x.

DOI:10.1016/0378-4274(85)90058-x
PMID:4039080
Abstract

A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatinum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with one of these metals, suggesting possible participation in this protection of mechanisms other than MT induction by the preadministered metals.

摘要

相似文献

1
Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice.
Toxicol Lett. 1985 Feb-Mar;24(2-3):203-7. doi: 10.1016/0378-4274(85)90058-x.
2
Tissue-specific induction of metallothionein by bismuth as a promising protocol for chemotherapy with repeated administration of cis-diamminedichloroplatinum (II) against bladder tumor.铋对金属硫蛋白的组织特异性诱导作为一种有前景的方案，用于顺二氯二氨铂（II）重复给药治疗膀胱肿瘤的化疗。
Anticancer Res. 1992 Nov-Dec;12(6B):2303-7.
3
Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice.通过诱导金属硫蛋白合成预防顺二氯二氨铂（II）的致死性和肾毒性，同时不损害其在小鼠中的抗肿瘤活性。
Cancer Res. 1987 Feb 15;47(4):983-7.
4
Effect of preinduction of metallothionein on paraquat toxicity in mice.
Arch Toxicol. 1992;66(2):145-8. doi: 10.1007/BF02342510.
5
Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart.
Toxicology. 1988 Dec 30;53(2-3):231-7. doi: 10.1016/0300-483x(88)90216-8.
6
Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis-diamminedichloroplatinum.柠檬酸盐可增强口服碱式硝酸铋对顺二氨二氯铂肾毒性的保护作用。
Cancer Chemother Pharmacol. 2004 Jan;53(1):33-8. doi: 10.1007/s00280-003-0706-9. Epub 2003 Oct 7.
7
[Detoxifying effect of lisheng-se on cisplatin and its relation to metallothionein induction].[力生硒对顺铂的解毒作用及其与金属硫蛋白诱导的关系]
Zhonghua Zhong Liu Za Zhi. 1994 Jul;16(4):280-3.
8
Induction of renal metallothionein allows increasing dose of an extensively used antitumor drug, cis-diamminedichloroplatinum.
Experientia Suppl. 1987;52:655-60. doi: 10.1007/978-3-0348-6784-9_70.
9
Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination.
Cancer Chemother Pharmacol. 1988;21(2):176-8. doi: 10.1007/BF00257369.
10
The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture.金属硫蛋白对大鼠原代肝细胞培养中各种金属毒性的保护作用。
Toxicol Appl Pharmacol. 1991 Jan;107(1):27-34. doi: 10.1016/0041-008x(91)90327-b.

引用本文的文献

1
WR2721 as a modulator of cisplatin- and carboplatin-induced side effects in comparison with other chemoprotective agents: a molecular approach.与其他化学保护剂相比，WR2721作为顺铂和卡铂诱导副作用的调节剂：一种分子方法。
Cancer Chemother Pharmacol. 1993;33(2):93-106. doi: 10.1007/BF00685326.
2
Metallothionein and anticancer agents: the role of metallothionein in cancer chemotherapy.金属硫蛋白与抗癌药物：金属硫蛋白在癌症化疗中的作用
J Neurooncol. 1993 Aug;17(2):123-9. doi: 10.1007/BF01050214.
3
Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination.
Cancer Chemother Pharmacol. 1988;21(2):176-8. doi: 10.1007/BF00257369.
4
Specific reduction of toxic side effects of adriamycin by induction of metallothionein in mice.通过诱导小鼠体内金属硫蛋白特异性降低阿霉素的毒副作用。
Jpn J Cancer Res. 1988 Mar;79(3):406-11. doi: 10.1111/j.1349-7006.1988.tb01605.x.
5
Zinc acetate pretreatment ameliorates cisplatin-induced Sertoli cell dysfunction in Sprague-Dawley rats.醋酸锌预处理可改善顺铂诱导的Sprague-Dawley大鼠睾丸支持细胞功能障碍。
Cancer Chemother Pharmacol. 1989;24(3):177-80. doi: 10.1007/BF00300239.
6
Metallothionein-like proteins and cell resistance to cis-dichlorodiammineplatinum(II) in L1210 cells.金属硫蛋白样蛋白与L1210细胞对顺二氯二氨铂（II）的细胞抗性
Cancer Chemother Pharmacol. 1990;25(6):411-7. doi: 10.1007/BF00686051.
7
Experimental basis for increasing the therapeutic index of cis-diamminedicarboxylatocyclobutaneplatinum(II) in brain tumor therapy by a high-zinc diet.通过高锌饮食提高顺-二氨基二羧酸环丁烷铂（II）在脑肿瘤治疗中治疗指数的实验依据。
Cancer Chemother Pharmacol. 1992;29(3):219-26. doi: 10.1007/BF00686256.