Sugiyama S, Miyazaki Y, Nagai S, Ozawa T
Arzneimittelforschung. 1985;35(1):26-7.
Using dog erythrocytes, the effect of coenzyme Q10 (CoQ10) on the resistance of the erythrocyte membrane was investigated. Hemolysis was induced either by Octoxinol (Triton X-100) a well-known detergent, or by hypotonic salines. Although no detectable CoQ10 was observed in erythrocyte without CoQ10 addition, the increment in CoQ10 content in erythrocyte was found to be proportional to the doses of CoQ10 added to the erythrocyte samples. Administration of CoQ10 inhibited significantly the hemolysis induced either by octoxinol or hypotonic salines by a dose-dependent manner. These results suggest that CoQ10 incorporated into the erythrocyte increased the resistance of erythrocyte membrane by a direct structural effect on the membrane.
利用犬红细胞，研究了辅酶Q10（CoQ10）对红细胞膜抗性的影响。溶血是由知名去污剂辛苯昔醇（曲拉通X-100）或低渗盐水诱导的。尽管在未添加CoQ10的红细胞中未观察到可检测到的CoQ10，但发现红细胞中CoQ10含量的增加与添加到红细胞样品中的CoQ10剂量成正比。CoQ10的给药以剂量依赖的方式显著抑制了由辛苯昔醇或低渗盐水诱导的溶血。这些结果表明，掺入红细胞的CoQ10通过对膜的直接结构作用增加了红细胞膜的抗性。
