Gez E, Catane R, Pfau L, Biran S
Gynecol Oncol. 1985 May;21(1):18-22. doi: 10.1016/0090-8258(85)90227-6.
Thirty-seven patients with advanced malignancies, who received cis-platinum-based combination chemotherapy, were evaluated for the antiemetic efficacy of high-dose metoclopramide. Most of the patients suffered from ovarian carcinoma. The dose of metoclopramide was 7.5 or 10 mg/kg per course. A total of 69 courses were given to 37 patients and in 22% of the courses, nausea and vomiting were eliminated altogether. In an additional 48% of the courses, a partial protection from chemotherapy-induced emesis was evident. No serious side effects were observed. The administration of high-dose metoclopramide is recommended for prevention of cis-platinum chemotherapy-induced emesis.
对37例接受以顺铂为基础的联合化疗的晚期恶性肿瘤患者，评估了大剂量甲氧氯普胺的止吐疗效。大多数患者患有卵巢癌。甲氧氯普胺的剂量为每疗程7.5或10mg/kg。37例患者共接受了69个疗程的治疗，其中22%的疗程中恶心和呕吐完全消除。在另外48%的疗程中，明显有部分预防化疗引起的呕吐的作用。未观察到严重的副作用。推荐使用大剂量甲氧氯普胺预防顺铂化疗引起的呕吐。
