Naik Parvaiz Ahmad, Farman Muhammad, Jamil Saba, Saleem Muhammad Umer, Nisar Kottakkaran Sooppy, Huang Zhengxin
Department of Mathematics and Computer Science, Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Art and Science Faculty, Department of Mathematics, Near East University, Boulevard, Nicosia/Mersin, Turkey.
PLoS One. 2025 May 20;20(5):e0320906. doi: 10.1371/journal.pone.0320906. eCollection 2025.
The numerical simulation of biological processes with non-integer ordering is attracting an increasing amount of interest from scientists and academics. Traditional biological systems can be presented in a fixed order, but fractional-order derivative systems are not considered stable orders. When the fractional derivative has a non-fixed order, it becomes more useful for simulating real-world problems. In this paper, we aim to study the dynamics of a novel technique that we propose, implement, and use in a radiation model for the treatment of cancer. We present some intriguing results for the cancer treatment fractal fractional model in the context of this innovative operator. Research has been done on the cancer model in both qualitative and quantitative manners. The first and second derivatives of the Lyapunov function are used to analyze the stability of the cancer fractal fractional model. Using the linear growth theory, the existence of a unique solution has been derived under the FFM. Lagrangian-piece-wise interpolation has been used to obtain numerical results for various fractal-fractional operators. The fractal fractional model was used to simulate the treatment process of three patients. Different values of fractional order [Formula: see text], fractal dimension [Formula: see text], and other parameter values have been used to show the graphs. Additionally, we looked at how radiation changed both healthy cells and malignant cells over time. The study confirmed the effectiveness of radiation medicine against populations as well as the occurrence of the memory effect during [Formula: see text] and [Formula: see text] transitions from 1. A biological process requires fractal-fractional processes which provide superior modeling capabilities compared to traditional fractional operators as well as classical operators. This research brings novel significance through its implementation of fractal-fractional operators as they provide a superior approach to model cancer treatment processes by better representing biological system complexities. Standard modeling systems cannot reproduce both important memory dynamics together with non-local communication patterns which play essential roles in cancer development and treatment analysis. The implementation of fractal-fractional derivatives enables our model to produce a more realistic representation of cancer cell and healthy cell radiotherapy responses throughout time. Our study has upgraded theoretical cancer dynamic analysis and developed optimized treatment methods for customization purposes. Wider understanding of cancer cell reactions to treatments enables healthcare providers to adopt personalized strategies that produce superior recovery outcomes for their patients. The model acquires stability strength through Lyapunov functions analysis to create a solid scientific foundation in oncology research.
具有非整数阶数的生物过程数值模拟正吸引着越来越多科学家和学者的关注。传统生物系统可以用固定阶数来表示,但分数阶导数系统不被认为是稳定的阶数。当分数阶导数具有非固定阶数时,它在模拟现实世界问题时变得更有用。在本文中,我们旨在研究一种我们提出、实现并应用于癌症治疗辐射模型的新技术的动力学。在这种创新算子的背景下,我们给出了癌症治疗分形分数模型的一些有趣结果。对癌症模型进行了定性和定量研究。利用李雅普诺夫函数的一阶和二阶导数来分析癌症分形分数模型的稳定性。利用线性增长理论,在分形分数模型(FFM)下推导了唯一解的存在性。采用拉格朗日分段插值法得到了各种分形分数算子的数值结果。分形分数模型用于模拟三名患者的治疗过程。使用了不同的分数阶值[公式:见原文]、分形维数[公式:见原文]和其他参数值来绘制图表。此外,我们研究了辐射随时间如何改变健康细胞和恶性细胞。该研究证实了放射医学对群体的有效性以及在从1开始的[公式:见原文]和[公式:见原文]转变过程中记忆效应的出现。生物过程需要分形分数过程,与传统分数算子以及经典算子相比,分形分数过程具有更强的建模能力。这项研究通过实施分形分数算子带来了新的意义,因为它们通过更好地表示生物系统复杂性,为癌症治疗过程建模提供了一种更优的方法。标准建模系统无法同时重现重要的记忆动力学以及在癌症发展和治疗分析中起关键作用的非局部通信模式。分形分数导数的实施使我们的模型能够在整个时间内更真实地表示癌细胞和健康细胞的放射治疗反应。我们的研究提升了癌症动力学的理论分析,并为定制目的开发了优化的治疗方法。对癌细胞对治疗反应的更广泛理解使医疗保健提供者能够采用个性化策略,为患者带来更好的治疗效果。该模型通过李雅普诺夫函数分析获得稳定性强度,为肿瘤学研究奠定了坚实的科学基础。