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基于 Mittag-Leffler 核的时标测度分段混合分数算子在埃博拉病毒流行中的建模与分析。

Modeling and analysis using piecewise hybrid fractional operator in time scale measure for ebola virus epidemics under Mittag-Leffler kernel.

机构信息

Department of Mathematics and Computer Science, Youjiang Medical University for Nationalities, 533000, Baise, Guangxi, China.

Faculty of Arts and Sciences, Department of Mathematics, Near East University, Northern Cyprus, Turkey.

出版信息

Sci Rep. 2024 Oct 23;14(1):24963. doi: 10.1038/s41598-024-75644-2.

DOI:10.1038/s41598-024-75644-2
PMID:39443508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11500182/
Abstract

This emerging infectious disease poses one of the most severe threats to public health in these locations, but there are not many reliable therapies yet. In this work, we developed the Ebola virus dynamics and control factors epidemic model with a piecewise hybrid fractional Operator in time scale measure insight of Mittag-Leffler kernel. Patterns and structures that repeat at various scales are the focus of fractal analysis, which has applications in complex systems such as biological ones. Both qualitatively and statistically, a proposed model with the Lipschitz criteria and linear growth is examined, considering positive solutions, boundedness, and uniqueness at equilibrium points with Leray-Schauder results under time scale ideas. The regulation for linear responses approach will be used by Chaos Control to stabilize the system after its equilibrium points. A fractional-order framework with a controlled design will be considered, where solutions are bounded in the feasible domain of relations of different compartments. Ulam-Hyers stability results in the solution are treated when function (constant or rising) for the component of qualitative inquiry in generalized form. The dynamical behaviors of the suggested model are discussed with the Newton polynomial approach used to implement on model in the sense of classical piecewise and Mittag-Leffler kernel at different fractional order values. The model shows that solutions are stable and confined within a feasible range, ensuring reliability. Through detailed simulations, it effectively captures how different interventions and infection rates influence Ebola spread. This fractional-order model enhances understanding of Ebola transmission, providing a strong basis for predicting outbreaks and planning effective control measures, with practical applications for analyzing real-world data.

摘要

这种新出现的传染病对这些地区的公共卫生构成了最严重的威胁之一,但目前还没有多少可靠的治疗方法。在这项工作中,我们开发了一种带有分段混合分数算子的埃博拉病毒动力学和控制因素流行模型,该模型基于 Mittag-Leffler 核的时间尺度测度洞察力。分形分析的重点是在不同尺度上重复出现的模式和结构,它在生物等复杂系统中有应用。在时间尺度思想下,使用 Lipschitz 准则和线性增长来检查具有正解、平衡点有界性和唯一性的提出模型,并使用 Leray-Schauder 结果考虑平衡点的稳定性。混沌控制将使用线性响应方法的调节来稳定系统的平衡点。将考虑具有控制设计的分数阶框架,其中解决方案在不同隔间关系的可行域内有界。当定性研究的组件函数(常数或上升)为广义形式时,将处理解的分数阶框架中的 Ulam-Hyers 稳定性结果。通过牛顿多项式方法来讨论所建议模型的动态行为,该方法用于在不同分数阶值下实现经典分段和 Mittag-Leffler 核意义上的模型。该模型表明解决方案是稳定的,并且在可行范围内受限,从而确保了可靠性。通过详细的模拟,可以有效地捕捉到不同干预措施和感染率如何影响埃博拉病毒的传播。这种分数阶模型增强了对埃博拉病毒传播的理解,为预测疫情和制定有效的控制措施提供了坚实的基础,在分析实际数据方面具有实际应用价值。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad35/11500182/97ffe0c1d35b/41598_2024_75644_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad35/11500182/155a36d754a4/41598_2024_75644_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad35/11500182/f45b3c732601/41598_2024_75644_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad35/11500182/01600f279ef7/41598_2024_75644_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad35/11500182/ec867c101331/41598_2024_75644_Fig11_HTML.jpg
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