Moon Sung Jin, Lee Sae Hyun, Sim Woo Hyun, Choi Han Suk, Lee Ju Seok, Shim Sangrea
Department of Forest Resources, College of Forest and Environmental Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Department of Agriculture, Forestry and Bioresources, College of Agriculture & Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Sci Data. 2025 May 20;12(1):827. doi: 10.1038/s41597-025-05214-2.
Elsholtzia splendens, a perennial herb native to East Asia, is valued for its ornamental and medicinal uses, particularly in treating inflammatory and febrile conditions. Recent studies have highlighted its antibacterial, anti-inflammatory, antidepressant, antithrombotic, and lipid-lowering properties of its compounds. Additionally, E. splendens shows potential for phytoremediation owing to its ability to hyperaccumulate copper (Cu), lead (Pb), zinc (Zn), and cadmium (Cd). However, its role in remediation conflicts with its medicinal use because of the risk of heavy metal accumulation. Genome sequencing will be key to boosting beneficial compound production and reducing heavy metal risks. In this study, we generated a high-resolution, haplotype-resolved, chromosome-scale genome sequence of E. splendens using PacBio Revio long-read, Illumina short-read, and Hi-C sequencing technologies. The haplotype genome assemblies, spanned 275.4 and 265.0 Mbp with a scaffold N50 of 33.9 and 33.8 Mbp for haplotype 1 and 2, respectively. This assembly provides valuable insights into medicinal compound biosynthesis and supports genetic conservation efforts, facilitating future genetic and biotechnological applications of E. splendens for medicinal and ecological uses.
海州香薷是一种原产于东亚的多年生草本植物，因其观赏和药用价值而受到重视，尤其在治疗炎症和发热病症方面。最近的研究突出了其化合物的抗菌、抗炎、抗抑郁、抗血栓形成和降脂特性。此外，海州香薷由于能够超积累铜（Cu）、铅（Pb）、锌（Zn）和镉（Cd），因而具有植物修复的潜力。然而，由于存在重金属积累的风险，其在修复中的作用与其药用价值相冲突。基因组测序将是提高有益化合物产量和降低重金属风险的关键。在本研究中，我们使用PacBio Revio长读长、Illumina短读长和Hi-C测序技术，生成了海州香薷的高分辨率、单倍型解析、染色体级别的基因组序列。单倍型基因组组装分别跨越275.4和265.0 Mbp，单倍型1和2的支架N50分别为33.9和33.8 Mbp。该组装为药用化合物生物合成提供了有价值的见解，并支持遗传保护工作，促进海州香薷未来在药用和生态用途方面的遗传和生物技术应用。
