环状 RNA 在哺乳动物卵巢的生理和病理中的作用。

The Role of Circular RNAs in the Physiology and Pathology of the Mammalian Ovary.

机构信息

College of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing 211169, China.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

出版信息

Int J Mol Sci. 2022 Dec 2;23(23):15204. doi: 10.3390/ijms232315204.

DOI:10.3390/ijms232315204

PMID:36499522

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9737273/

Abstract

Circular RNAs (circRNAs) are an abundant class of endogenous non-coding RNAs (ncRNAs) generated from exonic, intronic, or untranslated regions of protein-coding genes or intergenic regions. The diverse, stable, and specific expression patterns of circRNAs and their possible functions through cis/trans regulation and protein-coding mechanisms make circRNA a research hotspot in various biological and pathological processes. It also shows practical value as biomarkers, diagnostic indicators, and therapeutic targets. This review summarized the characteristics, classification, biogenesis and elimination, detection and confirmation, and functions of circRNAs. We focused on research advances circRNAs in the mammalian ovary under conditions including ovarian cancer, polycystic ovarian syndrome (PCOS), and maternal aging, as well as during reproductive status, including ovarian follicle development and atresia. The roles of circRNAs in high reproductive traits in domestic animals were also summarized. Finally, we outlined some obstructive factors and prospects to work with circRNA, aiming to provide insights into the functional research interests of circRNAs in the reproduction and gynecology areas.

摘要

环状 RNA（circRNAs）是一类丰富的内源性非编码 RNA（ncRNAs），它们来源于蛋白编码基因的外显子、内含子或非翻译区，或位于基因间区。circRNAs 的多样化、稳定和特异性表达模式，以及它们通过顺式/反式调控和蛋白编码机制发挥功能的可能性，使其成为各种生物学和病理学过程中的研究热点。circRNA 还具有作为生物标志物、诊断指标和治疗靶点的实际价值。本综述总结了 circRNAs 的特征、分类、生物发生和消除、检测和确认以及功能。我们重点介绍了在哺乳动物卵巢中，circRNAs 在卵巢癌、多囊卵巢综合征（PCOS）和母体衰老等条件下，以及在生殖状态下，包括卵泡发育和闭锁过程中的研究进展。还总结了 circRNAs 在家畜高繁殖性状中的作用。最后，我们概述了与 circRNA 相关的一些障碍因素和前景，旨在为 circRNA 在生殖和妇科领域的功能研究提供一些思路。