Lücker P W, Venitz J, Hennings G, Rehn D, Albrecht H, Alcorn G
Arzneimittelforschung. 1985;35(2):539-42.
The antiinflammatory activity of three preparations (cream, ointment, jelly) of Fenistil Plus (betamethasone + dimethindene maleate) was shown by means of reflection densitometry, a new pharmacodynamic model. The three preparations led to restitution of the Tesafilm-stripped skin within 4 h. There was no significant difference in the efficacy of the preparations. After application of 10 g of the ointment the plasma levels of betamethasone remained within the limits of identification of the analytical method. An influence of the drug on the endogenous plasma hydrocortisone (cortisol) levels could not be found.
通过反射光密度测定法这一新型药效学模型，研究了复方苯吡胺（倍他米松+马来酸氯苯那敏）的三种制剂（乳膏、软膏、凝胶）的抗炎活性。这三种制剂均可在4小时内使胶带剥离皮肤恢复原状。各制剂的疗效无显著差异。涂抹10克软膏后，倍他米松的血浆水平仍在分析方法的检测范围内。未发现该药物对血浆中内源性氢化可的松（皮质醇）水平有影响。
