Hersh J H, Podruch P E, Rogers G, Weisskopf B
J Pediatr. 1985 Jun;106(6):922-7. doi: 10.1016/s0022-3476(85)80238-9.
Three children with microcephaly, central nervous system dysfunction, minor craniofacial and limb anomalies, and variable growth deficiency were born to women who inhaled large quantities of pure toluene throughout pregnancy. The features in our patients were reminiscent of the patterns of malformation previously described following in utero exposure to alcohol, certain anticonvulsants, and hyperphenylalaninemia. It is possible that there is a variable and nonspecific teratogenic phenotype characterized by alterations in growth, development, and morphogenesis. Careful evaluation and monitoring of infants exposed to toluene in utero are needed to determine the significance of our findings.
三名患有小头畸形、中枢神经系统功能障碍、轻微颅面和肢体异常以及不同程度生长发育迟缓的儿童，其母亲在整个孕期吸入了大量纯甲苯。我们患者的这些特征使人联想到先前描述的子宫内暴露于酒精、某些抗惊厥药和高苯丙氨酸血症后的畸形模式。有可能存在一种以生长、发育和形态发生改变为特征的可变且非特异性致畸表型。需要对子宫内暴露于甲苯的婴儿进行仔细评估和监测，以确定我们研究结果的意义。
