Hersh J H
Department of Pediatrics, University of Louisville, Kentucky 40202.
J Med Genet. 1989 May;26(5):333-7. doi: 10.1136/jmg.26.5.333.
Toluene embryopathy is characterised by microcephaly, central nervous system dysfunction, attentional deficits and hyperactivity, developmental delay with greater language deficits, minor craniofacial and limb anomalies, and variable growth deficiency. Previously, three affected children, born to women who inhaled toluene regularly throughout pregnancy, have been reported. Two more cases are described emphasising the importance of toluene as a potential human teratogen.
甲苯胚胎病的特征为小头畸形、中枢神经系统功能障碍、注意力缺陷和多动、伴有更严重语言缺陷的发育迟缓、轻微的颅面和肢体异常以及生长发育不足。此前,已有报道称3名受影响儿童的母亲在整个孕期均有规律地吸入甲苯。本文描述了另外2例病例,强调了甲苯作为一种潜在人类致畸物的重要性。