胃排空对镇痛药美普他酚血浆浓度的影响。
The influence of gastric emptying on plasma concentrations of the analgesic, meptazinol.
作者信息
Franklin R A
出版信息
Br J Pharmacol. 1977 Apr;59(4):565-9. doi: 10.1111/j.1476-5381.1977.tb07722.x.
Abstract
- The influence of gastric emptying on the rate of absorption and peak plasma concentrations of meptazinol was studied in monkeys by comparison of the plasma concentrations of the drug achieved after intragastric and intraduodenal administration of the compound. Absorption was much more rapid and plasma concentrations were very much higher after intraduodenal than after intragastric dosage. 2. Determination of the 'normal' gastric emptying time in rats and monkeys showed that this was much longer in the monkey than in the rat. In addition, meptazinol was shown to have a pronounced retarding action on gastric emptying in the monkey, an effect which was not apparent in the rat. 3. The significance of these observations in relation to the species difference in oral potency of the drug is discussed.
摘要
- 通过比较胃内和十二指肠内给予美普他酚后所达到的药物血浆浓度，在猴子身上研究了胃排空对美普他酚吸收速率和血浆峰浓度的影响。十二指肠给药后吸收比胃内给药快得多，且血浆浓度也高得多。2. 对大鼠和猴子的“正常”胃排空时间的测定表明，猴子的胃排空时间比大鼠长得多。此外，美普他酚对猴子的胃排空有明显的延迟作用，而在大鼠中未观察到这种作用。3. 讨论了这些观察结果与该药物口服效力的种属差异之间的关系。
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本文引用的文献
1
The effect of morphine sulfate on gastric motility; some radiologic observations in man.
Gastroenterology. 1957 Jan;32(1):88-95.
2
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J Pharmacol Exp Ther. 1953 Dec;109(4):393-400.
3
Pentazocine effects on gastrointestinal motor functions in man.喷他佐辛对人体胃肠运动功能的影响。
Am J Gastroenterol. 1967 Oct;48(4):295-310.
4
Physiologic correlates dependent upon mode of death.
Toxicol Appl Pharmacol. 1967 Mar;10(2):253-60. doi: 10.1016/0041-008x(67)90108-1.
5
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Arch Int Pharmacodyn Ther. 1966 Sep;163(1):38-46.
6
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Chem Pharm Bull (Tokyo). 1971 May;19(5):944-53. doi: 10.1248/cpb.19.944.
7
Total recovery studies of nonabsorbable indicators in the rat small intestine.大鼠小肠中不可吸收指示剂的总回收率研究。
Gastroenterology. 1970 Jan;58(1):40-6.
8
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Chem Biol Interact. 1971 Aug;3(4):291. doi: 10.1016/0009-2797(71)90065-2.
9
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J Pharm Sci. 1972 Jun;61(6):945-7. doi: 10.1002/jps.2600610627.
10
Some properties of WY 22811, a new analgesic compound.新型镇痛化合物WY 22811的某些特性
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